Left Atrial Distensibility and Left Ventricular Filling Pressure in Acute Myocardial Infarction
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|ClinicalTrials.gov Identifier: NCT01168609|
Recruitment Status : Completed
First Posted : July 23, 2010
Last Update Posted : July 23, 2010
|Condition or disease||Intervention/treatment|
|Myocardial Infarction||Procedure: Primary percutaneous coronary intervention|
|Study Type :||Observational|
|Actual Enrollment :||521 participants|
|Official Title:||Usefulness of Left Atrial Distensibility to Assess Left Ventricular Filling Pressure and to Predict Prognosis in Acute Myocardial Infarction|
|Study Start Date :||December 2007|
|Actual Primary Completion Date :||March 2009|
|Actual Study Completion Date :||July 2010|
patients with acute myocardial infarction
Acute myocardial infarction (AMI) was defined using the European Society of Cardiology / American College of Cardiology guidelines. Myocardial infarction was detected by the presence of at least two of the following criteria: chest pain lasting more than 30 minutes, typical electrocardiographic changes, and elevated creatinine kinase-MB fraction. Consecutive patients 18 years of age or older who presented within 12 hours after the onset of symptoms were considered for enrollment. Patients who had ST-segment elevation of 1 mm or more in two or more contiguous leads were classified as ST-segment elevation MI.
Procedure: Primary percutaneous coronary intervention
Primary percutaneous coronary intervention (PCI) and stenting were performed for just the culprit lesion using standard techniques and bare-metal stents in all patients. Unfractionated heparin was used for 3 days after PCI, except in some cases with contraindications, and the dose of unfractionated heparin was selected to prolong the activated partial thromboplastin time by 2-3 times. The decision to use glycoprotein IIb/IIIa inhibitors was left to the discretion of the treating physician. The measurements of LVFP were performed via a fluid-filled pig-tail catheter placed into the LV after coronary angiography if PCI was not indicated or after primary PCI.
- in-hospital death after acute myocardial infarction [ Time Frame: Average 2 weeks ]All cause mortality during index hospitalization of acute myocardial infarction was recorded.
- 1-year hard event rate after acute myocardial infarction [ Time Frame: 1 year after discharge ]After index hospitalization, patients were followed up at our cardiovascular clinic for at least 1 year. A follow-up survey assessing hard cardiovascular (CV) events was carried out after discharge. All cause mortality and heart failure with re-hospitalization were defined as hard CV event. Follow-up was performed between December 2007 and February 2010 by telephone interviews, medical record reviews, and home visits.
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01168609
|Kaohsiung Veterans General Hospital|
|Kaohsiung, Taiwan, 886|
|Study Chair:||Jong-Khing Huang, MD||Department of Medical Education and Research Kaohsiung Veterans General Hospital|