Relationship and Pathophysiology of Gastroesophageal Reflux and Dental/Periodontal Disease
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|ClinicalTrials.gov Identifier: NCT01167543|
Recruitment Status : Completed
First Posted : July 22, 2010
Last Update Posted : July 22, 2010
This study investigates the prevalence and pathophysiology of dental and periodontal involvement in pediatric patients with symptomatic or asymptomatic gastroesophageal reflux (GER) or gastroesophageal reflux disease (GERD). Primary objectives are to compare the prevalence of oral disease in children with and without a diagnosis or symptoms/signs of GERD in a cross-sectional study. Secondary objectives are to examine factors that might lead to the pathogenesis of the dental and periodontal lesions observed in this group of subjects.
The primary hypothesis is to prove that children aged 10-18 years diagnosed with or having symptoms or signs of GERD have a significantly higher amount of dental erosions in comparison to a matched control group.
Secondary hypotheses are that children aged 10 - 18 years diagnosed with or having signs of GER have higher DMFS (Decayed, Missing, Filled permanent tooth Surfaces) rates, higher SBI (Sulcus Bleeding Index) rates, worse Periodontal status, and lower saliva buffering capacity.
|Condition or disease|
|Gastroesophageal Reflux Dental Erosion|
|Study Type :||Observational|
|Actual Enrollment :||79 participants|
|Observational Model:||Case Control|
|Study Start Date :||September 2005|
|Actual Study Completion Date :||November 2008|
|Pediatric patients with symptoms or diagnosis of GER|
|Control group of pediatric subjects with no symptoms of GER.|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01167543
|United States, California|
|University of California, San Francisco Dental School|
|San Francisco, California, United States, 94143|