Effect of Electrostimulation in Chronic Obstructive Pulmonary Disease (COPD) (ExaEMS2005)
This study was designed to test the following hypothesis:
To investigate whether COPD muscles can respond to stimuli in terms of changes in fiber-type distribution.
|Chronic Obstructive Pulmonary Disease||Device: Electrostimulation Device: Sham stimulation|
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Participant)
|Official Title:||Effect of Electromyostimulation in Severe Chronic Obstructive Pulmonary Disease|
- Fiber-type distribution [ Time Frame: 6 to 8 weeks ]Typology was evaluated by immunohistochemistry
- Change in the strength of the quadriceps over the 6-week electrostimulation program [ Time Frame: 6 to 8 weeks ]
|Study Start Date:||July 2006|
|Study Completion Date:||April 2010|
|Primary Completion Date:||April 2010 (Final data collection date for primary outcome measure)|
Active Comparator: Electrostimulation
Neuromuscular electrical stimulation
Electrostimulation: 35 Hz, 0.4 ms, 1 h; 5 times/week
Other Name: NMES
Sham Comparator: Sham stimulation
Device: Sham stimulation
Sham stimulation: 1 h; 5 times/week
Other Name: Sham
Background: Muscle dysfunction is a major problem in chronic obstructive pulmonary disease (COPD). It is characterized by muscle fiber-type redistribution and oxidative stress. Classical training does not improve these features.
Objectives: To investigate whether electrostimulation program following exacerbation can modify muscle structure and function in COPD patients.
Method: We propose to conduct a controlled and randomized clinical trial comparing the efficacy of muscle electrostimulation training of the lower limbs to sham training in 15 patients with COPD. Patients are included in either 6 weeks of electrostimulation training (active treatment group) or 6 weeks of sham electrostimulation. Primary outcomes were changes in muscle structure, muscle oxidative stress and their relationship with quadriceps force and exercise tolerance.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01167283
|Principal Investigator:||Olivier OJ Jonquet, PU-PH||Institut National de la Santé Et de la Recherche Médicale, France|