Detailed Clinical, Biochemical and Genetic Characterization in Gonadotropin-releasing Hormone (GnRH) Deficiency Disorders
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01165619|
Recruitment Status : Terminated (the Principal Investigator left the institution)
First Posted : July 20, 2010
Last Update Posted : May 24, 2011
|Condition or disease|
|Idiopathic Hypogonadotropic Hypogonadism Hypothalamic Amenorrhea|
|Study Type :||Observational|
|Actual Enrollment :||50 participants|
|Official Title:||Detailed Clinical, Biochemical and Genetic Characterization in GnRH Deficiency Disorders|
|Study Start Date :||June 2010|
|Actual Primary Completion Date :||October 2010|
|Actual Study Completion Date :||October 2010|
This group is for pre-menopausal women between the aged 18-40 who have been previously diagnosed with Hypothalamic Amenorrhea. They can be currently diagnosed or may have recovered.
Healthy Adult Men
This group is men over the age of 18 who do not have any history of reproductive disorders or chronic disease.
Healthy Adult Women
This group is pre-menopausal, regularly menstruating women ages 18-40 who do not have a history of reproductive disorders or chronic disease.
Idiopathic Hypogonadotropic Hypogonadism
This group is for adult men and women over the age of 18 who have been diagnosed with Idiopathic Hypogonadotropic Hypogonadism with or without anosmia.
- Serum/plasma markers [ Time Frame: baseline ]At the study visit, serum and plasma samples will be taken to measure levels of reproductive hormones and metabolic markers in the subjects' blood.
- Genetics [ Time Frame: baseline ]At the study visit, blood will be taken and DNA cell lines will be made to screen for genes that potentially contribute to the development of reproductive disorders
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01165619
|United States, Massachusetts|
|Massachusetts General Hospital|
|Boston, Massachusetts, United States, 02114|