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Creatine Supplementation and Cognition

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ClinicalTrials.gov Identifier: NCT01164020
Recruitment Status : Completed
First Posted : July 16, 2010
Last Update Posted : January 18, 2013
Sponsor:
Information provided by (Responsible Party):
Bruno Gualano, University of Sao Paulo

Brief Summary:
Resistance training as well as creatine supplementation may be beneficial for cognitive function, such as memory and attention. Therefore, the investigators speculate that resistance training combined with creatine supplementation would promote additive benefits on cognitive function in elderly women.

Condition or disease Intervention/treatment Phase
Cognition Aging Dietary Supplement: creatine supplementation Other: Placebo (Dextrose) Other: Resistance training Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 56 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Prevention
Study Start Date : August 2010
Actual Primary Completion Date : December 2012
Actual Study Completion Date : December 2012

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arm Intervention/treatment
Placebo Comparator: placebo control
this only receives placebo (dextrose)
Other: Placebo (Dextrose)
20g/d for 7 days followed by 5g/d for 23 weeks
Experimental: placebo and exercise
this is trained and receives placebo
Other: Placebo (Dextrose)
20g/d for 7 days followed by 5g/d for 23 weeks
Other: Resistance training
resistance training twice a week for 24 weeks
Experimental: creatine supplementation
this is non-exercise trained and receives creatine supplementation
Dietary Supplement: creatine supplementation
20g/d for 7 days followed by 5g/d for 23 weeks
Experimental: Creatine and Exercise
this is exercised trained and receives creatine supplementation
Dietary Supplement: creatine supplementation
20g/d for 7 days followed by 5g/d for 23 weeks
Other: Resistance training
resistance training twice a week for 24 weeks



Primary Outcome Measures :
  1. cognitive function [ Time Frame: six months ]

Secondary Outcome Measures :
  1. physical capacity [ Time Frame: six months ]
    muscle strength and function



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Ages Eligible for Study:   60 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • women older than 60 years old

Exclusion Criteria:

  • cardiovascular diseases or muscular disturbances precluding exercise training
  • drugs affecting the cognition

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01164020


Locations
Brazil
School of Medicine - Division of Rheumatology
São Paulo, Brazil, 05508-030
Sponsors and Collaborators
University of Sao Paulo
Investigators
Principal Investigator: Bruno Gualano, PhD University of Sao Paulo
Principal Investigator: Antonio H Lancha Junior, PhD University of Sao Paulo

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Bruno Gualano, Principal Investigator, University of Sao Paulo
ClinicalTrials.gov Identifier: NCT01164020     History of Changes
Other Study ID Numbers: Creatine and Cognition
First Posted: July 16, 2010    Key Record Dates
Last Update Posted: January 18, 2013
Last Verified: January 2013

Keywords provided by Bruno Gualano, University of Sao Paulo:
cognition
supplementation creatine
resistance training
aging