Phonomotor Treatment of Word Retrieval Deficits in Individuals With Aphasia

This study has been completed.
Information provided by (Responsible Party):
VA Office of Research and Development Identifier:
First received: July 14, 2010
Last updated: July 9, 2015
Last verified: July 2015

This is a behavioral speech therapy trial for individuals who have suffered a stroke on the left side of the brain and have difficulty speaking. The name of this disorder is called 'aphasia'. Individuals who participate in this study will receive 60 hours of therapy for free (2 hours/day, 5 days/week, 6 weeks).

Condition Intervention Phase
Behavioral: speech therapy
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Real Word Effects in Phonological Treatment for Word Retrieval

Resource links provided by NLM:

Further study details as provided by VA Office of Research and Development:

Primary Outcome Measures:
  • Speech Production [ Time Frame: Baseline to one week post treatment termination and three months post treatment termination ] [ Designated as safety issue: No ]
    percent change in the number of untrained words spoken correctly

Enrollment: 28
Study Start Date: September 2010
Study Completion Date: September 2014
Primary Completion Date: June 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Immediate Treatment
individuals will receive 60 hours of speech therapy
Behavioral: speech therapy
individuals will receive 60 hours of behavioral speech therapy
Experimental: Delayed Treatment
individuals will receive 60 hours of speech therapy after 6 week delay period
Behavioral: speech therapy
individuals will receive 60 hours of behavioral speech therapy

Detailed Description:

The study design was a single group (n=26) with repeated testing (3 times) pre- and post-treatment. All participants received the same treatment protocol (described in detail in Appendix A and in Minkina et al. (under review)). In order to control for improvement in language function related to passage of time, and for the effect of repeated exposure to outcome measures, individuals were randomly assigned to one of two conditions: delayed treatment or immediate treatment (Figure 2). Participants who were randomized to the delayed group received repeated testing three times before and three times after a six-week delay. During the delay phase they were permitted to participate in usual speech-language care (e.g., conversation groups and individual therapy).

Standardized assessments and outcome measures (described in detail below) were administered prior to the start of treatment (for both immediate and delayed groups), at the end of the delay phase (delayed group only), immediately after treatment termination, and at three months post-treatment.


Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • left hemisphere stroke
  • monolingual English speaking
  • right handed
  • presence of aphasia

Exclusion Criteria:

  • preexisting neurological condition
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01163461

United States, Washington
VA Puget Sound Health Care System, Seattle
Seattle, Washington, United States, 98108
Sponsors and Collaborators
VA Office of Research and Development
Principal Investigator: Diane L. Kendall, PhD VA Puget Sound Health Care System, Seattle
  More Information

Responsible Party: VA Office of Research and Development Identifier: NCT01163461     History of Changes
Other Study ID Numbers: C6572-R
Study First Received: July 14, 2010
Results First Received: September 29, 2014
Last Updated: July 9, 2015
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Communication Disorders
Language Disorders
Nervous System Diseases
Neurobehavioral Manifestations
Neurologic Manifestations
Signs and Symptoms
Speech Disorders processed this record on October 08, 2015