Seroepidemiology of Japanese Encephalitis Virus Infection in Hualien, Taiwan
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ClinicalTrials.gov Identifier: NCT01163123 |
Recruitment Status
: Unknown
Verified July 2010 by Mennonite Christian Hospital.
Recruitment status was: Enrolling by invitation
First Posted
: July 15, 2010
Last Update Posted
: July 16, 2010
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Condition or disease |
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Japanese Encephalitis |
According to CDC Taiwan epidemiology data, Hualien county had 6 confirmed JEV infection patients in 2009 witch was the highest county in Taiwan. Since mass vaccination was arranged since 45 years ago in Taiwan, most of the JEV infection was happened on the elderly, possible due to aging and immune compromised. However, from Mennonite Christian Hospital and CDC records, most of the confirmed JEV patients in Hualien county were aboriginal people. The youngest patient in 2009 is around 30-year-old who lived in the mountain side aboriginal village. Whether aboriginal people are at more risk for JEV infection or Genotype I JEV was appeared in Hualien with more virulent, resistent to vaccine protection is unknown.
In order to understand the risk of JEV infection and environmental (mosquito, swine) surveillance, we had arranged a small cohort study in 2 villages. The 2 villages are located at middle Hualien with direct distance around 20 KM between each other. Both villages had several pig farms and mosquito numbers in summer were very high. Both villages had document JEV infection resident in past 2 years. The first village was near the river ready to entrance the sea (wetlands) and many migrate birds appeared in the summer every year. The residence were mostly Han people. The seconds village was located very closed to the central mountain Taiwan and the residence were almost aboriginal people.
In this year 2010, we plan to do the following research:
- Collect mosquito in 2 villages since May.2010 with RT-PCT method to identify the JEV genotype
- Collect sera from swine in 2 villages to identify the JEV genotype
- Collect sera from 312 residency in 2 villages at May and Sep 2010 to detect sub-clinical infection rate. ( estimated sub-clinical infection rate = 2.5%)
- Identify the JEV from new diagnosed patient in 2010.
Since virus was hardly detected by RT-PCR or virus isolation from JEV infected patient, the virus identified from mosquito or swine in the nearby may show indirect evidence of the JEV genotype.
After comparing the 2 sera from the same person during the summer in these 2 villages, we can identify:
- The subclinical infection rate of the JEV (genotype I or III, depends on JEV isolated from mosquito)
- Whether aboriginal people near the central mountains are at more risk then people near the wetlands.
Study Type : | Observational |
Estimated Enrollment : | 312 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Seroepidemiology of Japanese Encephalitis Virus Infection in Hualien, Taiwan |
Study Start Date : | May 2010 |
Estimated Primary Completion Date : | December 2010 |
Estimated Study Completion Date : | December 2010 |

- Measure the subclinical infection rate in the cohort population during the summer ( May 2010 ~ Sep 2010) [ Time Frame: May 2010 - Oct 2010 ]
We exam 2 sera from volunteer collected seperately on May and October 2010 to estimate the subclinical infection rate. Subclinical infection rate was defined by one of the following
- 4 times increased in IgG titer
- Appearance of IgM in the second sera
- Apperance of Anti-NS1 antibody in the second sera
Biospecimen Retention: Samples Without DNA

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Ages Eligible for Study: | 18 Years to 85 Years (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Living in the specific 2 villages in Hualien county
- Aged 18-85
Exclusion Criteria:
1. Difficulty to have blood test due to coagulopathy or small blood vessels

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01163123
Study Director: | ChenChang Shih |
Responsible Party: | Sheng-Hsuan Chen, Mennonite Christian Hospital |
ClinicalTrials.gov Identifier: | NCT01163123 History of Changes |
Other Study ID Numbers: |
D9902 |
First Posted: | July 15, 2010 Key Record Dates |
Last Update Posted: | July 16, 2010 |
Last Verified: | July 2010 |
Keywords provided by Mennonite Christian Hospital:
Subclinical infection of Japanese encephalitis virus |
Additional relevant MeSH terms:
Encephalitis, Japanese Infection Virus Diseases Encephalitis Brain Diseases Central Nervous System Diseases Nervous System Diseases Encephalitis, Arbovirus |
Arbovirus Infections Encephalitis, Viral Central Nervous System Viral Diseases RNA Virus Infections Flavivirus Infections Flaviviridae Infections Infectious Encephalitis Central Nervous System Infections |