1,5-AG as a Marker of Postprandial Hyperglycemia and Glucose Variability in Well-controlled Type 2 Diabetes Mellitus
The aim of this study was to evaluate the correlation between 1,5-Anhydroglucitol in patients with HbA1C <7%, and glycemic excursions as assessed by the continuous glucose monitoring system compared to fructosamine.
Type 2 Diabetes Mellitus
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Correlation Between 1,5-anhydroglucitol and Postprandial Hyperglycemia by Continuous Glucose Monitoring System and Clinical Usefulness of 1,5-anhydroglucitol in Well-controlled Diabetic Patients|
- postprandial hyperglycemia [ Time Frame: 3days ] [ Designated as safety issue: No ]
- glucose variability [ Time Frame: 3 days ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
serum (HbA1c, fructosamine, 1,5-anhydroglucitol)
|Study Start Date:||February 2008|
|Study Completion Date:||July 2010|
1,5-Anhydroglucitol (AG) is a glucose analogue present in the plasma of healthy subjects. Physiologically, the plasma levels of 1,5-AG are very stable and only a small quantity is excreted in the urine. It is competitively reabsorbed with glucose in the renal tubules. Therefore, in the hyperglycemic state where glycosuria is present, glucose competitively inhibits renal tubular reabsorption of 1,5-AG and consequently the plasma 1,5-AG levels decrease. When glycemia is normalized and glycosuria is resolved, 1,5-AG levels increase.
The usefulness of 1, 5-AG in reflecting glycemic excursions have been demonstrated in moderately controlled patients to some extent, although some studies reveal controversial results.
Therefore, the aim of this study was to evaluate the association of 1,5-AG and postprandial hyperglycemia determined using the Continuous Glucose Monitoring System (CGMS) in DM patients with HbA1C<7% and evaluate the usefulness of 1,5-AG as a marker of glycemic control compared to HbA1C and fructosamine.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01161797
|Korea, Republic of|
|Kyunghee University Medical Center|
|Seoul, Korea, Republic of, 130-702|
|Study Director:||Jeong-taek Woo, MD, PhD||Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea|