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Effect of a Combined Use of Mosquito Repellent and Insecticide Treated Net on Malaria in Ethiopia

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ClinicalTrials.gov Identifier: NCT01160809
Recruitment Status : Completed
First Posted : July 12, 2010
Last Update Posted : July 12, 2010
Information provided by:

Study Description
Brief Summary:
The combined use of a mosquito repellent and long lasting insecticidal nets (LLINs) by household members would result in a 40% reduction in malaria prevalence compared with households that only use LLINs.

Condition or disease Intervention/treatment Phase
Malaria Mosquito Repellent Long Lasting Insecticidal Nets Other: Mosquito repellent Phase 4

Detailed Description:
It has been recognized that the use of malaria preventive measures in combination with LLINs could improve the effectiveness of nets in preventing the disease. This study examined the effect of a combined use of mosquito repellent (i.e., Buzz Off) and LLINs on malaria prevalence in an area of unstable and seasonal malaria transmission.

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 6082 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Effect of a Combined Use of Mosquito Repellent and Insecticide Treated Net on Malaria in Southern Ethiopia: a Cluster-randomized Controlled Trial
Study Start Date : September 2008
Primary Completion Date : December 2008
Study Completion Date : January 2009

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arms and Interventions

Arm Intervention/treatment
Experimental: Mosquito repellent and LLINs group vs. LLINs group only
This study is based on two population groups: 1) a group of households that use LLINs alone (control) and 2) a group of households that use both mosquito repellent and LLINs (repellent group).
Other: Mosquito repellent
Mosquito repellent (Buzz Off jelly) every evening applied to face, neck, hands and legs

Outcome Measures

Primary Outcome Measures :
  1. Malaria parasite (P. falciparum and/or P. vivax)through microscopic detection
    The objective of the study is to investigate the impact of a combined use of mosquito repellent and LLINs in reducing malaria. The primary outcome of the study is detection of malaria parasites (P. falciparum and/or P. vivax) through examination of microscopic blood slides collected from finger-pricks.

Secondary Outcome Measures :
  1. Household ownership and utilization of LLINs
    Owneship and utilization of LLINs by household members during the night before the baseline survey

Eligibility Criteria

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • All volunteer household members

Exclusion Criteria:

  • Infants less than two months
  • Not in the study area
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01160809

SNNPR, Ethiopia
Awassa, Snnpr, Ethiopia
Sponsors and Collaborators
Malaria Consortium, Ethiopia
Addis Ababa University
Columbia University
Coalition Against Malaria in Ethiopia
More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Dr. Wakgari Deressa, School of Public Health, Addis Ababa University, Ethiopia
ClinicalTrials.gov Identifier: NCT01160809     History of Changes
Other Study ID Numbers: 0001
First Posted: July 12, 2010    Key Record Dates
Last Update Posted: July 12, 2010
Last Verified: July 2010

Keywords provided by Malaria Consortium, Ethiopia:
Mosquito repellent

Additional relevant MeSH terms:
Protozoan Infections
Parasitic Diseases