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Screening for Atrial Fibrillation, After Ischemic Stroke

This study has been completed.
Information provided by:
Karolinska Institutet Identifier:
First received: July 9, 2010
Last updated: June 22, 2011
Last verified: June 2011

The aim of the study is to assess the incidence of patients suffering from ischemic stroke or transient ischemic attacks who have underlying asymptomatic paroxysmal atrial fibrillation.

Patients who have suffered an ischemic stroke or transient ischemic attack, without a history of atrial fibrillation, are planned to be included. Starting within 14 days of the ischemic stroke, participating patients are asked to perform 10 second ECG recordings using a handheld ECG device twice daily (mornings and evenings) during 30 days. These recordings are transmitted via telephone to a secure encrypted Internet site. Within these 30 days the participants also perform an ambulatory 24 hour Holter recording. Handheld ECG recordings are evaluated continuously. In case of atrial fibrillation the patient is informed and offered treatment with anti coagulant medication (Warfarin). The investigation is a comparison between 24 hour continuous ECG recordings and short intermittent ECG recordings twice daily over a longer time period to determine which method is the best to detect atrial fibrillation in this patient group.

Hypothesis: Short Intermittent ECG recordings over a longer time period is more efficient, compared with continuous 24 hour ECG recordings, in detecting silent paroxysmal AF in patients with an ischemic stroke and without a history of atrial fibrillation.

Atrial Fibrillation Stroke

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Improving Screening for Silent Atrial Fibrillation, After Ischemic Stroke

Resource links provided by NLM:

Further study details as provided by Karolinska Institutet:

Estimated Enrollment: 250
Study Start Date: June 2007
Study Completion Date: November 2010
Primary Completion Date: November 2010 (Final data collection date for primary outcome measure)
ischemic stroke, no atrial fibrillation
Patients who have suffered ischemic stroke or transient ischemic attack without known atrial fibrillation


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients from hospital strokewards.

Inclusion Criteria:

  • No previously diagnosed atrial fibrillation.
  • Acute ischemic stroke or transient ischemic attack verified by computed tomography or clinical diagnosis using the National Institute of Health Stroke Score within 14 days of enrollment.
  • Ability to understand study instructions both verbal and written.
  • Ability to perform and transmit ECG recordings according to study design.

Exclusion Criteria:

  • Previously diagnosed atrial fibrillation.
  • Hemorrhagic stroke
  • Low compliance
  • Pacemaker carrier
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01160406

Halmstad hospital
Halmstad, Halland, Sweden, 30180
South hospital
Stockholm, Sweden, 11883
Danderyds hospital AB
Stockholm, Sweden, 18288
Sponsors and Collaborators
Karolinska Institutet
Study Director: Mårten Rosenqvist, M.D.Ph.D. Karolinska Institutet
  More Information

Responsible Party: Mårten Rosenqvist M.D. Ph.D., Karolinska Institutet Identifier: NCT01160406     History of Changes
Other Study ID Numbers: KI-DSAB-2010
Study First Received: July 9, 2010
Last Updated: June 22, 2011

Keywords provided by Karolinska Institutet:
silent paroxysmal atrial fibrillation
tele ECG

Additional relevant MeSH terms:
Atrial Fibrillation
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Arrhythmias, Cardiac
Heart Diseases
Pathologic Processes processed this record on September 19, 2017