Now Available: Final Rule for FDAAA 801 and NIH Policy on Clinical Trial Reporting

Is Cryosurgery or Curettage More Effective at Treating Seborrheic Keratoses?

This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
Lance Wood, Milton S. Hershey Medical Center Identifier:
First received: July 9, 2010
Last updated: August 24, 2011
Last verified: June 2010

Seborrheic keratoses (SK's) are very common, but harmless skin lesions that commonly appear during adult life. Patients with seborrheic keratoses frequently desire treatment due to symptoms of itching and irritation or for cosmetic purposes. Seborrheic keratoses can be easily removed and have been treated in a number of different ways. Two of the simplest and most successful ways to remove seborrheic keratoses are cryosurgery and curettage.

The investigators are conducting this study to see which of these two treatments has the best result.

Approximately 24-30 people will take part in this research study at the Hershey Medical Center.

Condition Intervention
Seborrheic Keratosis
Procedure: cryosurgery
Procedure: Curettage

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Factorial Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Treatment
Official Title: Is Cryosurgery or Curettage More Effective at Treating Seborrheic Keratoses?

Resource links provided by NLM:

Further study details as provided by Milton S. Hershey Medical Center:

Primary Outcome Measures:
  • Partial or complete resolution of treated lesion. [ Time Frame: 6 weeks ] [ Designated as safety issue: No ]
    Follow up evaluation by a blinded physician along with the gathering of patient information via questionnaires will be obtained at the completion of the study.

Estimated Enrollment: 30
Study Start Date: July 2010
Estimated Study Completion Date: October 2011
Estimated Primary Completion Date: October 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Cryosurgery
One lesion on the patients' trunk or proximal extremities will be treated with cryosurgery.
Procedure: cryosurgery
freezing of lesion with liquid nitrogen
Active Comparator: Curettage
One lesion on one side of the patients' trunk or proximal extremities will be treated by curettage.
Procedure: Curettage
the lesion will be anesthetized and destroyed with a curette.


Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Genders Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • have at least 1 seborrheic keratosis on each side of his/her trunk or proximal extremities.
  • be able to understand the consent form and evaluation of treatment questionnaire.

Exclusion Criteria:

  • Children <18 are excluded from this study based on their inability to independently complete the informed consent and research associated questionnaire.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01159860

United States, Pennsylvania
Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
Sponsors and Collaborators
Milton S. Hershey Medical Center
Principal Investigator: Lance D. Wood, M.D. Milton S. Hershey Medical Center
  More Information

Responsible Party: Lance Wood, Lance D. Wood, MD, Penn State Milton S. Hershey Medical Center, Milton S. Hershey Medical Center Identifier: NCT01159860     History of Changes
Other Study ID Numbers: IRB Protocol No. 33895 
Study First Received: July 9, 2010
Last Updated: August 24, 2011
Health Authority: United States: Institutional Review Board

Keywords provided by Milton S. Hershey Medical Center:
seborrheic keratoses

Additional relevant MeSH terms:
Keratosis, Actinic
Keratosis, Seborrheic
Skin Diseases
Precancerous Conditions
Neoplasms processed this record on January 18, 2017