This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

The Rate of C-reactive Protein (CRP) Increase as a Marker for Bacterial Infections in Children (CRPv)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified July 2010 by Shaare Zedek Medical Center.
Recruitment status was:  Not yet recruiting
Information provided by:
Shaare Zedek Medical Center Identifier:
First received: July 8, 2010
Last updated: NA
Last verified: July 2010
History: No changes posted

Fever is one of the most common problems in pediatrics. Differentiating between bacterial infections, that require antibiotic therapy, and viral infections that resolve on their own is an important challenge for physicians.

C-reactive protein (CRP) is a protein that increases in response to inflammation and its level is generally higher in bacterial infections compared to viral infections. it can be measured by a simple blood test, however its utility as a sole marker for bacterial infection is limited.

The hypothesis of the study is that measuring CRP velocity, e.g the value of CRP divided by the hours since the fever started will improve the utility of CRP for the diagnosis of bacterial infections in children.

Bacterial Infections Viral Infection

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: CRP Velocity as a Marker for Bacterial Infections in Children

Resource links provided by NLM:

Further study details as provided by Shaare Zedek Medical Center:

Estimated Enrollment: 200
Study Start Date: September 2010
Estimated Study Completion Date: September 2011
Estimated Primary Completion Date: September 2011 (Final data collection date for primary outcome measure)
bacterial infection
children with fever due to bacterial infection
viral infection
children with fever due to viral infection


Ages Eligible for Study:   up to 5 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
children < 5 years of age presenting to the Emergency Department with fever

Inclusion Criteria:

  • children less than 5 years of age,
  • children with no comorbidities and fever > 38 for at least 24 hours, and
  • children with no previous antibiotic therapy.

Exclusion Criteria:

  • HIV,
  • immunosuppressive conditions,
  • antibiotic therapy.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

No Contacts or Locations Provided
  More Information

Responsible Party: Maskit Bar-Meir, MD, Shaare-Zedek Medical Center Identifier: NCT01159470     History of Changes
Other Study ID Numbers: 472010.ctil
Study First Received: July 8, 2010
Last Updated: July 8, 2010

Keywords provided by Shaare Zedek Medical Center:
CRP velocity

Additional relevant MeSH terms:
Communicable Diseases
Bacterial Infections
Virus Diseases processed this record on September 19, 2017