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The Effect of Local Injectet GH on the Collagen Synthesis in the Ligamentum Patella

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01158612
First Posted: July 8, 2010
Last Update Posted: November 7, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Bispebjerg Hospital
Information provided by (Responsible Party):
University of Aarhus
  Purpose
Tendon and ligament injuries are a frequent problem among athletes but also in the general population. The healing process is a prolonged process, and complete recovery of tissue strength is nearly never reached. The purpose of this study is to examine the effect of local injection of human Growth Hormone on tendon collagen synthesis.

Condition Intervention
Growth Hormone Elderly Drug: Growth Hormone

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary Purpose: Treatment
Official Title: The Effect of Local Injectet GH on the Collagen Synthesis in the Ligamentum Patella

Resource links provided by NLM:


Further study details as provided by University of Aarhus:

Primary Outcome Measures:
  • • Fraktionele collagen protein synthesis in human patella tendon [ Time Frame: 01122010 ]

Enrollment: 12
Study Start Date: August 2010
Study Completion Date: August 2011
Primary Completion Date: July 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Growth hormone
The effect of Growth hormone on the collagen synthesis rate
Drug: Growth Hormone
infusion of Growth hormone in the patella tendon.
Other Name: infusion of Saline in the patella tendon.
Placebo Comparator: Saline Drug: Growth Hormone
infusion of Growth hormone in the patella tendon.
Other Name: infusion of Saline in the patella tendon.

Detailed Description:

Tendon and ligament injuries are a frequent problem among athletes but also in the general population. The healing process is a prolonged process, and complete recovery of tissue strength is nearly never reached. The purpose of this study is to examine the effect of local injection of human Growth Hormone on tendon collagen synthesis.

in order to investigate the collagen synthesis potential and the influence of growth hormone, 12 elderly males age > 50 year, is enrolled in this study.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   55 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • BMI 18.5 - 25.0

Exclusion Criteria:

  • earlier knee injury
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01158612


Locations
Denmark
Århus universitetshospital nørrebrogade 44
Århus C, Denmark, 8000
Sponsors and Collaborators
University of Aarhus
Bispebjerg Hospital
Investigators
Principal Investigator: Mette Hansen, PH.D.
  More Information

Responsible Party: University of Aarhus
ClinicalTrials.gov Identifier: NCT01158612     History of Changes
Other Study ID Numbers: H-2-2010-039
First Submitted: July 7, 2010
First Posted: July 8, 2010
Last Update Posted: November 7, 2011
Last Verified: November 2011

Additional relevant MeSH terms:
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs