Remote Ischemic Preconditioning in Subarachnoid Hemorrhage (RIPC-SAH)
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT01158508 |
Recruitment Status
:
Completed
First Posted
: July 8, 2010
Last Update Posted
: November 28, 2016
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Subarachnoid Hemorrhage, Aneurysmal Subarachnoid Hemorrhage Cerebral Vasospasm Intracranial Aneurysm | Procedure: Remote ischemic preconditioning | Phase 1 |

Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 20 participants |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Treatment |
Official Title: | Prophylactic Remote Ischemic Preconditioning for Cerebral Vasospasm Following Subarachnoid Hemorrhage |
Study Start Date : | April 2010 |
Actual Primary Completion Date : | January 2014 |
Actual Study Completion Date : | July 2014 |
Arm | Intervention/treatment |
---|---|
Experimental: Remote Ischemic Preconditioning
Patients with aneurysmal subarachnoid hemorrhage, after aneurysm treatment, will be given prophylactic remote ischemic preconditioning by transient lower limb ischemia.
|
Procedure: Remote ischemic preconditioning
Transient lower limb ischemia will be induced by inflation of a blood pressure cuff on the thigh. Four five minute cycles of ischemia will be performed, each followed by five minutes of reperfusion with the cuff down. This procedure will be performed in four rounds, typically on post-hemorrhage days 2, 3, 6 and 9.
|
- Occurrence of neurological events, or vasospasm [ Time Frame: At days 3 ]
- Occurrence of neurological events, or vasospasm [ Time Frame: At day 7 ]
- Occurrence of neurological events, or vasospasm [ Time Frame: At day 15 ]
- Occurrence of neurological events, or vasospasm [ Time Frame: At day 30 ]
- Transcranial Doppler Measurements and metabolic assessment [ Time Frame: At days 3 ]
- Transcranial Doppler Measurements and metabolic assessment [ Time Frame: At day 7 ]
- Transcranial Doppler Measurements and metabolic assessment [ Time Frame: At day 15 ]

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | Child, Adult, Senior |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Diagnosis of recent aneurysmal subarachnoid hemorrhage.
- Definitive treatment of the aneurysm by surgical clipping or endovascular coiling has been completed.
Exclusion Criteria:
- Patients with unprotected (untreated) cerebral aneurysms.
- Patients with a known history of lower limb vascular disease, lower limb vascular bypass surgery and/or peripheral neuropathy.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01158508
United States, California | |
UCLA Ronald Reagan Medical Center | |
Los Angeles, California, United States, 90095 |
Principal Investigator: | Nestor R Gonzalez, MD | University of California, Los Angeles David Geffen School of Medicine, Departments of Neurosurgery and Radiology |
Publications of Results:
Responsible Party: | University of California, Los Angeles |
ClinicalTrials.gov Identifier: | NCT01158508 History of Changes |
Other Study ID Numbers: |
09-08-081-01 |
First Posted: | July 8, 2010 Key Record Dates |
Last Update Posted: | November 28, 2016 |
Last Verified: | November 2016 |
Keywords provided by University of California, Los Angeles:
cerebral aneurysm cerebral vasospasm subarachnoid hemorrhage remote ischemic preconditioning |
Additional relevant MeSH terms:
Aneurysm Intracranial Aneurysm Brain Diseases Hemorrhage Subarachnoid Hemorrhage Vasospasm, Intracranial Pathologic Processes |
Vascular Diseases Cardiovascular Diseases Intracranial Hemorrhages Cerebrovascular Disorders Central Nervous System Diseases Nervous System Diseases Intracranial Arterial Diseases |