Oral Contraceptive Pill and GnRH Antagonist Versus Long Protocol in IVF Patients (Larganta)

This study has been completed.
Information provided by (Responsible Party):
IVI Madrid
ClinicalTrials.gov Identifier:
First received: July 6, 2010
Last updated: April 21, 2015
Last verified: April 2015
Recent controversy has arisen regarding the use of the pill for cycle planning in GnRH antagonist IVF cycles. The investigators performed this study to compare such a protocol with the gold-standard still today, which is the long-agonist protocol with no previous use of the pill.

Condition Intervention
Drug: levonorgestrel and ethynilestradiol

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Cycle Planning With OCP in GnRH Antagonists Cycles Versus Long Protocol in Good Prognosis IVF Patients

Resource links provided by NLM:

Further study details as provided by IVI Madrid:

Primary Outcome Measures:
  • implantation rate [ Time Frame: 2 weeks after the embryo transfer ] [ Designated as safety issue: No ]

Enrollment: 115
Study Start Date: June 2009
Study Completion Date: June 2010
Primary Completion Date: May 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: OCP+GnRH antagonist
Microgynon 14 to 21 tablets starting COH on day 5 post pill, rFSH + GnRH antagonist
Drug: levonorgestrel and ethynilestradiol
Active Comparator: long GnRH agonist
daily triptorelin starting day 21st of previous cycle
Drug: levonorgestrel and ethynilestradiol


Ages Eligible for Study:   18 Years to 38 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • 1st or 2nd IVF cycle
  • BMI <30 kg/m2
  • regular menstrual cycles
  • basal FSH <10 IU and E2 <60 pg/ml

Exclusion Criteria:

  • Polycystic ovaries
  • endometriosis
  • previous ovarian surgery
  • previous low ovarian response
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01157754

Instituto Valenciano de Infertilidad
Madrid, Spain, 28035
Sponsors and Collaborators
IVI Madrid
  More Information

Responsible Party: IVI Madrid
ClinicalTrials.gov Identifier: NCT01157754     History of Changes
Other Study ID Numbers: MAD-GV-05-2009-01 
Study First Received: July 6, 2010
Last Updated: April 21, 2015
Health Authority: Spain: Comité Ético de Investigación Clínica

Keywords provided by IVI Madrid:
Infertility patients requiring IVF
good prognosis

Additional relevant MeSH terms:
Genital Diseases, Female
Genital Diseases, Male
Contraceptives, Oral
Contraceptives, Oral, Combined
Contraceptive Agents
Contraceptive Agents, Female
Contraceptives, Oral, Synthetic
Physiological Effects of Drugs
Reproductive Control Agents

ClinicalTrials.gov processed this record on May 26, 2016