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Homeopathic Remedy for the Third Stage of Delivery

This study has been completed.
Information provided by (Responsible Party):
Menachem Oberbaum, Shaare Zedek Medical Center Identifier:
First received: July 1, 2010
Last updated: February 19, 2012
Last verified: February 2012

The homeopathic remedy consisting of Arnica and Bellis perennis have been shown in a previous pilot study (n=33) to reduce blood loss during the third stage of delivery, when compared with placebo treatment. The purpose of this study is to repeat the previous methodology, this time on a larger population.

210 parturients will be randomized to one of three groups: Arnica montana C6 and Bellis perennis C6 (n=70), Arnica montana C30 and Bellis perennis C30 (n=70), or double placebo (n=70).

Condition Intervention Phase
Third Stage of Labor
Drug: Homeopathy 1
Drug: Homeopathy 2
Drug: Placebo
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Effect of a Homeopathic Remedy on the Third Stage of Delivery: a Prospective, Randomized, Double-Blind Study.

Further study details as provided by Shaare Zedek Medical Center:

Primary Outcome Measures:
  • Hemoglobin levels at 2d postpartum [ Time Frame: 48h ]

Secondary Outcome Measures:
  • incidence of endometritis [ Time Frame: 7d ]
  • time to extrusion of placenta following birth [ Time Frame: 24h ]
  • duration of lochiae secretion [ Time Frame: 7days ]
  • duration of third stage of labor [ Time Frame: 24h ]
  • assessment of quality-of-life parameters [ Time Frame: 7 days ]
  • assess toxic effects of the homeopathic remedies [ Time Frame: 7 days ]
  • serum cortisol levels [ Time Frame: within 12h postpartum ]
  • state of perineum postpartum [ Time Frame: 48h ]

Estimated Enrollment: 210
Study Start Date: January 2011
Study Completion Date: January 2012
Primary Completion Date: January 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Homeopathy 1
Arnica montana C6 and Bellis perennis C6
Drug: Homeopathy 1
Arnica montana C6 and Bellis perennis C6
Active Comparator: Homeopathy 2
Arnica montana C30 and Bellis perennis C30
Drug: Homeopathy 2
Arnica montana C30 and Bellis perennis C30
Placebo Comparator: Placebo
globules identical to true comparators
Drug: Placebo
globule identical to true homeopathy comparators


Ages Eligible for Study:   20 Years to 35 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • healthy women in 3rd stage of labor
  • age 20-35
  • second to fifth gestation
  • spontaneous PV delivery
  • term delivery (37-42nd weeks)

Exclusion Criteria:

  • scarred uterus
  • multifetal pregnancy
  • history of bleeding problems
  • caesarian section delivery
  • chorioamnionitis
  • pregnancy-induced hypertension
  • gestational diabetes mellitus
  • polyhydramnios, premature rupture of membrane
  • suspected macrosomy/SGA
  Contacts and Locations
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Please refer to this study by its identifier: NCT01156194

Maternity Ward, Shaare Zedek Medical Center
Jerusalem, Israel, 91031
Sponsors and Collaborators
Shaare Zedek Medical Center
  More Information

Responsible Party: Menachem Oberbaum, Director, Center for Integrative Complementary Medicine, Shaare Zedek Medical Center Identifier: NCT01156194     History of Changes
Other Study ID Numbers: ArBel.2010
Study First Received: July 1, 2010
Last Updated: February 19, 2012

Keywords provided by Shaare Zedek Medical Center:
third stage, labor, postpartum hemorrhage, homeopathy, arnica, bellis perennis processed this record on April 28, 2017