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Asthma is a chronic disease that affects nearly 13% of adults in the U.S., causing substantial impairment that is reflected in the tens of millions of missed days of work, and doctors' and emergency room visits it leads to annually. Those who have asthma are twice as likely to develop depression and anxiety, which are associated with more frequent and severe asthma symptoms, especially in those under chronic stress. The project proposed here seeks to understand the role of the brain in these associations and to evaluate the neural mechanisms through which a safe, low-cost intervention, that influences the function of body via the mind, may diminish the expression of asthma symptoms.
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Ages Eligible for Study:
18 Years to 45 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Physician diagnosed asthma with previous use of asthma medication
negative skin-prick test to cat dander or house dust mite and have no history of asthma
score 3 or above on any subscale of the UCLA (University of California Los Angeles) chronic stress interview
No chronic stress:
score 1.5 or below on all subscales of the UCLA chronic stress interview
Individuals with severe asthma, or those whom currently require the use of corticosteroids
Individuals with significant medical problems
Individuals who smoke cigarettes
Individuals a previous adverse reaction to corticosteroids, a recent (< 1 month) viral illness, a history of severe asthma or anaphylaxis.
Breastfeeding women or women who are, suspect they might be or are trying to become pregnant