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Procalcitonin as a Marker for the Length of Antibiotic Treatment in Peritonitis and Intra-abdominal Infections

This study has been completed.
Information provided by (Responsible Party):
Nicolas DEMARTINES, University of Lausanne Hospitals Identifier:
First received: July 23, 2009
Last updated: December 18, 2014
Last verified: December 2014
Procalcitonin level used for determining length of antibiotic treatment in peritonitis and intra-abdominal infections. Hypothesis is that length of antibiotic use can be shortened by this method.

Secondary or Tertiary Peritonitis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Etude Prospective Sur l'Impact de l'Utilisation de la Procalcitonine Dans l'évaluation de la Poursuite ou de l'arrêt du Traitement Antibiotique Empirique Lors de péritonites et d'Infections Intra-abdominales

Resource links provided by NLM:

Further study details as provided by Nicolas DEMARTINES, University of Lausanne Hospitals:

Primary Outcome Measures:
  • antibiotic treatment length, hospitalisation length without antibiotic, infection recurrence, antibiotic cost [ Time Frame: at one month and during hospital stay ]

Enrollment: 162
Study Start Date: June 2009
Study Completion Date: June 2014
Primary Completion Date: June 2014 (Final data collection date for primary outcome measure)
procalcitonine monitoring
PCT group: antibiotic use is tailored by serum procalcitonin values, determined every 48houres.
control group
control group: antibiotic use and length of treatment as defined by guidelines

Detailed Description:
Prospective randomized trial

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
hospitalized patients with SIRS due to peritonitis or intra-abdominal infections

Inclusion Criteria:

  • More than 18 yo
  • Patient requiring surgery for peritonitis or intra-abdominal infection following: perforation, necrosis, previous operation...
  • Mannheim Peritonitis score > 14
  • SIRS present
  • Probability of survival > 72h
  • Informed consent by patient/relatives

Exclusion Criteria:

  • No SIRS
  • Long date corticoid treatment
  • Immunosuppression
  • Thyroid medullary carcinoma
  • Anaphylactic shock
  • Acute hepatic deficiency
  Contacts and Locations
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Please refer to this study by its identifier: NCT01155739

University Hospital of Lausanne
Lausanne, Switzerland, 1011
Sponsors and Collaborators
University of Lausanne Hospitals
Principal Investigator: Steve Aellen, MD Department of visceral surgery, university hospital
  More Information

Responsible Party: Nicolas DEMARTINES, professor of surgery, University of Lausanne Hospitals Identifier: NCT01155739     History of Changes
Other Study ID Numbers: 141/08, Propéritonite
Study First Received: July 23, 2009
Last Updated: December 18, 2014

Additional relevant MeSH terms:
Intraabdominal Infections
Peritoneal Diseases
Digestive System Diseases
Anti-Bacterial Agents
Antibiotics, Antitubercular
Anti-Infective Agents
Antitubercular Agents processed this record on September 21, 2017