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RETRIeVE: ReversE TranscRiptase Inhibitor hiV Practice

This study has been completed.
Information provided by (Responsible Party):
Dr. Mark Bloch, Holdsworth House Medical Practice Identifier:
First received: June 30, 2010
Last updated: September 17, 2015
Last verified: September 2015
An observational retrospective study of NNRTI experienced patients who have virologically failed. The study aims to assess resistance profiling and subsequent prescription patterns of patients on NNRTIs

HIV Positive

Study Type: Observational
Study Design: Time Perspective: Retrospective
Official Title: Non-nucleoside Reverse Transcriptase Inhibitor Failure in a High HIV Caseload Australian Primary Care Practice

Resource links provided by NLM:

Further study details as provided by Dr. Mark Bloch, Holdsworth House Medical Practice:

Primary Outcome Measures:
  • resistance profiling and subsequent prescription patterns of patients on NNRTIs [ Time Frame: 1 year ]

Enrollment: 2044
Study Start Date: June 2010
Study Completion Date: February 2013
Primary Completion Date: September 2011 (Final data collection date for primary outcome measure)
HIV1 positive, NNRTI exposure and failure

Detailed Description:
This is a cross-sectional study involving retrospective review of HIV-1 positive patient records who began treatment with a non-nucleoside reverse transcriptase inhibitor (NNRTI) and subsequently failed. Patients who have virologically failed previous NNRTI treatment, or have resistance to 1 drug in the NNRTI class are examined further. Such patients will have attended the clinic every 3-6 months for routine medical care. The data source for variables collected is the patient's electronic medical records. This database is located at Holdsworth House Medical Practice (HHMP), Sydney.

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Demographic information will be collected from patient medical records for all patients that have used previously, or are currently using an NNRTI as part of HIV treatment therapy.

Inclusion Criteria:

  1. Documented HIV infection
  2. Attended Holdsworth House Medical Practice 1999-2009.
  3. Chosen ART regime includes an NNRTI

Exclusion Criteria: N/A

  Contacts and Locations
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Please refer to this study by its identifier: NCT01154556

Australia, New South Wales
Holdsworth House Medical Practice
Darlinghurst, New South Wales, Australia, 2010
Sponsors and Collaborators
Holdsworth House Medical Practice
  More Information

Responsible Party: Dr. Mark Bloch, Principal Investigator, Holdsworth House Medical Practice Identifier: NCT01154556     History of Changes
Other Study ID Numbers: RETRIeVE
Study First Received: June 30, 2010
Last Updated: September 17, 2015

Keywords provided by Dr. Mark Bloch, Holdsworth House Medical Practice:
Antiretroviral therapy experienced
failed NNRTI regime

Additional relevant MeSH terms:
HIV Seropositivity
HIV Infections
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Reverse Transcriptase Inhibitors
Nucleic Acid Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents processed this record on May 25, 2017