Mechanisms of Stroke in Intracranial Stenosis (MoSIS)
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ClinicalTrials.gov Identifier: NCT01152944
Recruitment Status :
(The affiliated study SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis) has stopped enrollment.)
First Posted : June 29, 2010
Last Update Posted : February 7, 2012
Jose Romano, MD
National Institute of Neurological Disorders and Stroke (NINDS)
The objective of this SAMMPRIS-affiliated study is to understand the mechanisms the mechanisms that underlie ischemic stroke recurrence in high-grade intracranial atherosclerotic disease in order to determine predictors of recurrent stroke. MoSIS will evaluate 6 specific mechanisms of stroke in the medically-treated SAMMPRIS cohort: decreased antegrade flow, progression of stenosis, decreased proximal collateral flow, decreased distal collateral flow, impaired cerebrovascular reserve, and artery-to-artery embolism.
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Ages Eligible for Study:
30 Years to 80 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Medical arm of the SAMMPRIS trial which includes recently symptomatic (<30 days) high grade (70% or more)intracranial stenosis of the carotid, middle cerebral, vertebral or basilar arteries.
Enrolled in the medical arm of SAMMPRIS, signed consent
For QMRA testing: contraindications to MRI; for TCD testing, abscence of ultrasonographic windows.