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Paracetamol Metabolism in Post Operative Conditions

This study has been completed.
Information provided by:
University Hospital, Clermont-Ferrand Identifier:
First received: June 28, 2010
Last updated: NA
Last verified: June 2010
History: No changes posted
Follow-up of urinary concentration from paracetamol metabolites by patients with aortic surgery during 4 days therapeutic intake (perfalgan ® 4 x 1g IV/day)

Aortic Surgery and Treatment Post Operative With Paracetamol During 4 Days

Study Type: Observational
Study Design: Time Perspective: Cross-Sectional
Official Title: Paracetamol Metabolism in Post Operative Conditions

Resource links provided by NLM:

Further study details as provided by University Hospital, Clermont-Ferrand:

Primary Outcome Measures:
  • Follow-up of urinary concentration from paracetamol metabolites by patients with aortic surgery during 4 days therapeutic intake (perfalgan ® 4 x 1g IV/day) [ Time Frame: during 4 days therapeutic intake ]

Secondary Outcome Measures:
  • - Follow-up of glutathion concentration during 4 post operative days [ Time Frame: during 4 post operative days ]
  • Monitoring of liver function

Enrollment: 30
Study Start Date: June 2008
Study Completion Date: June 2010
Primary Completion Date: September 2008 (Final data collection date for primary outcome measure)
Detailed Description:

D-15 to D0: selection

  • patient information and non-opposition obtained
  • inclusion and non inclusion criteria check
  • clinical exam

D-1 to D0 : 24 hours diuresis

D0 : operation day

Before anesthesia :

  • urine collection (paracetamol metabolites dosage)
  • blood sampling (glutathion and liver function test)


  • 1st paracetamol intake before closing
  • Then administration every 6 hours

D1 to D4 :

  • 24 hours urine collection (metabolites dosage)
  • blood sampling et D1 and D4(glutathion and liver function test)

D5 : final clinical exam


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Defined population

Inclusion Criteria:

  • aortic surgery
  • treatment with intraveinous paracetamol (4 grammes daily during 4 days)
  • patient agrees to participate

Exclusion Criteria:

  • - patient disagrees
  • paracetamol contra-indication
  • paracetamol intake 5 days before surgery
  Contacts and Locations
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Please refer to this study by its identifier: NCT01152502

CHU Clermont-Ferrand
Clermont-Ferrand, France, 63003
Sponsors and Collaborators
University Hospital, Clermont-Ferrand
Principal Investigator: Eric SCHNEIDER University Hospital, Clermont-Ferrand
  More Information

Responsible Party: Patrick LACARIN, CHU Clermont-Ferrand Identifier: NCT01152502     History of Changes
Other Study ID Numbers: CHU-0076
Study First Received: June 28, 2010
Last Updated: June 28, 2010

Keywords provided by University Hospital, Clermont-Ferrand:
Post operative conditions, paracetamol metabolites

Additional relevant MeSH terms:
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Antipyretics processed this record on May 22, 2017