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The Effect of Oxytocin on Gastric Emptying

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01152047
First Posted: June 29, 2010
Last Update Posted: April 7, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Bodil Ohlsson, Skane University Hospital
  Purpose
The investigators have seen that oxytocin lowers satiety in healthy subjects. Patients with dyspepsia suffers from decreased accommodation and increased satiety postprandially. The investigators now want to examine whether oxytocin may diminish symptoms in these patients.

Condition Intervention
Dyspepsia Lack of Satiety Drug: oxytocin

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Double (Participant, Care Provider)
Primary Purpose: Treatment
Official Title: The Effect of Oxytocin on Satiety in Patients With Dyspepsia

Resource links provided by NLM:


Further study details as provided by Bodil Ohlsson, Skane University Hospital:

Primary Outcome Measures:
  • Satiety [ Time Frame: 2 h ]
    The investigator want to examine whether oxytocin leads to lower satiety scores after intake of the same volume of nutrient


Other Outcome Measures:
  • To see if oxytocin lowers satiety [ Time Frame: 2h ]
    To perform a drinking satiety test twice. Once with oxytocin and once with saline. Then examine whether oxytocin decreases satiety compared to saline


Enrollment: 14
Study Start Date: May 2010
Study Completion Date: April 2015
Primary Completion Date: April 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: oxytocin, satiety
Oxytocin is given as infusion to examine if this decreases satiety compared to saline during a drinking test
Drug: oxytocin
40mU/min as infusion of oxytocin
Other Name: syntocinon

Detailed Description:
Patients will come twice for a slow satiety drinking test. Once they will get saline infusion and once oxytocin 40 mU/min. At the same time they register satiety on a VAS scale.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Dyspepsia

Exclusion Criteria:

  • Age > 65 years
  • Cardiac disease
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01152047


Locations
Sweden
Skåne University Hospital
Malmö, Sweden, 205 02
Sponsors and Collaborators
Skane University Hospital
Investigators
Principal Investigator: Bodil Ohlsson, professor Divsion of Internal Medicine
  More Information

Responsible Party: Bodil Ohlsson, Department of Clinical Sciences, Division of Internal Medicine, Skane University Hospital
ClinicalTrials.gov Identifier: NCT01152047     History of Changes
Other Study ID Numbers: 2009/502
2009/502 ( Other Identifier: Regional Ethical Review Board )
First Submitted: June 23, 2010
First Posted: June 29, 2010
Last Update Posted: April 7, 2015
Last Verified: April 2015

Keywords provided by Bodil Ohlsson, Skane University Hospital:
oxytocin
satiety
dyspepsia

Additional relevant MeSH terms:
Dyspepsia
Signs and Symptoms, Digestive
Signs and Symptoms
Oxytocin
Oxytocics
Reproductive Control Agents
Physiological Effects of Drugs


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