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The Effect of Oxytocin on Gastric Emptying

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ClinicalTrials.gov Identifier: NCT01152047
Recruitment Status : Completed
First Posted : June 29, 2010
Last Update Posted : April 7, 2015
Sponsor:
Information provided by (Responsible Party):
Bodil Ohlsson, Skane University Hospital

Brief Summary:
The investigators have seen that oxytocin lowers satiety in healthy subjects. Patients with dyspepsia suffers from decreased accommodation and increased satiety postprandially. The investigators now want to examine whether oxytocin may diminish symptoms in these patients.

Condition or disease Intervention/treatment
Dyspepsia Lack of Satiety Drug: oxytocin

Detailed Description:
Patients will come twice for a slow satiety drinking test. Once they will get saline infusion and once oxytocin 40 mU/min. At the same time they register satiety on a VAS scale.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 14 participants
Intervention Model: Single Group Assignment
Masking: Double (Participant, Care Provider)
Primary Purpose: Treatment
Official Title: The Effect of Oxytocin on Satiety in Patients With Dyspepsia
Study Start Date : May 2010
Primary Completion Date : April 2015
Study Completion Date : April 2015

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Indigestion
Drug Information available for: Oxytocin
U.S. FDA Resources

Arm Intervention/treatment
Experimental: oxytocin, satiety
Oxytocin is given as infusion to examine if this decreases satiety compared to saline during a drinking test
Drug: oxytocin
40mU/min as infusion of oxytocin
Other Name: syntocinon



Primary Outcome Measures :
  1. Satiety [ Time Frame: 2 h ]
    The investigator want to examine whether oxytocin leads to lower satiety scores after intake of the same volume of nutrient


Other Outcome Measures:
  1. To see if oxytocin lowers satiety [ Time Frame: 2h ]
    To perform a drinking satiety test twice. Once with oxytocin and once with saline. Then examine whether oxytocin decreases satiety compared to saline



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Dyspepsia

Exclusion Criteria:

  • Age > 65 years
  • Cardiac disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01152047


Locations
Sweden
Skåne University Hospital
Malmö, Sweden, 205 02
Sponsors and Collaborators
Skane University Hospital
Investigators
Principal Investigator: Bodil Ohlsson, professor Divsion of Internal Medicine

Responsible Party: Bodil Ohlsson, Department of Clinical Sciences, Division of Internal Medicine, Skane University Hospital
ClinicalTrials.gov Identifier: NCT01152047     History of Changes
Other Study ID Numbers: 2009/502
2009/502 ( Other Identifier: Regional Ethical Review Board )
First Posted: June 29, 2010    Key Record Dates
Last Update Posted: April 7, 2015
Last Verified: April 2015

Keywords provided by Bodil Ohlsson, Skane University Hospital:
oxytocin
satiety
dyspepsia

Additional relevant MeSH terms:
Dyspepsia
Signs and Symptoms, Digestive
Signs and Symptoms
Oxytocin
Oxytocics
Reproductive Control Agents
Physiological Effects of Drugs