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Correlation Between Various Adipokines and Vascular Inflammation Measured by Positron Emission Tomography (PET) With 18F-fluoro-deoxyglucose (FDG) (18FDG-PET)

This study has been completed.
Information provided by:
Korea University Identifier:
First received: June 9, 2010
Last updated: June 28, 2010
Last verified: April 2010
The inflammatory state and composition of atherosclerotic plaques are considered the main contributing factors responsible for acute cardiovascular events, rather than the degree of stenosis. Recently, positron emission tomography (PET) with 18F-fluoro-deoxyglucose (FDG) has been suggested as a promising novel imaging technique to identify the inflammatory state of atherosclerotic plaque. Recently, a few clinical studies showed that circulating A-FABP level had a close relation with the development of atherosclerosis in human. Therefore, in the present study, the investigators examined the relationship between circulating A-FABP and vascular inflammation of carotid arteries measured using FDG-PET in healthy male subjects.

Condition Intervention
Other: Cross sectional study

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Correlation Between Various Adipokines and Vascular Inflammation Measured by 18FDG-PET In Healthy Male Subjects

Resource links provided by NLM:

Further study details as provided by Korea University:

Primary Outcome Measures:
  • Vascular inflammation in carotid arterial wall, represented as the target-to-background ratio (TBR), using FDG-PET [ Time Frame: 12 weeks ]

Secondary Outcome Measures:
  • Circulating serum A-FABP levels [ Time Frame: 12 weeks ]
  • Circulating serum leptin levels [ Time Frame: 12weeks ]
  • Circulating serum adiponectin levels [ Time Frame: 12 weeks ]
  • Carotid intima-media thickness levels measured using ultrasonography [ Time Frame: 12 weeks ]

Biospecimen Retention:   Samples Without DNA
whole blood, plasma, serum

Enrollment: 90
Study Start Date: April 2010
Study Completion Date: June 2010
Primary Completion Date: June 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Healthy male participants Other: Cross sectional study
This is not intervention study. The purpose of the study is to examine the relationship between various adipokine levels and PET imaging at the cross section setting


Ages Eligible for Study:   20 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy male participats who underwent a medical health check in the health promotion center in Korea Guro University

Inclusion Criteria:

  • Healthy male volunteers for visiting routine medical check in our clinic

Exclusion Criteria:

  • History of cardiovascular disease (myocardial infarction, unstable angina,stroke, or cardiovascular revascularization)
  • Diabetes
  • Hypertension
  • Malignancy
  • Severe renal or hepatic disease
  • Subjects taking medications that might affect inflammation such as NSIAD and statin
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01150006

Korea, Republic of
Hye Jin Yoo
Seoul, Korea, Republic of, 152-703
Sponsors and Collaborators
Korea University
Principal Investigator: Kyung Mook Choi, MD.PhD Korea University
  More Information

Responsible Party: Name/Official Title: Kyung Mook Choi, Korea University Identifier: NCT01150006     History of Changes
Other Study ID Numbers: PET_Adipokines
Study First Received: June 9, 2010
Last Updated: June 28, 2010

Keywords provided by Korea University:
vascular inflammation
adipocyte fatty acid binding protein

Additional relevant MeSH terms:
Pathologic Processes
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases
Fluorodeoxyglucose F18
Molecular Mechanisms of Pharmacological Action processed this record on March 28, 2017