A Community Trial to Determine Whether 'Safe Storage' Reduces Pesticide Self-poisoning in Rural Asia
|Pesticide Poisoning||Device: Ultraviolet light-resistant plastic in-ground pesticide storage container|
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Prevention
|Official Title:||A Community Trial to Determine Whether 'Safe Storage' Reduces Pesticide Self-poisoning in Rural Asia|
- Incidence of pesticide self-poisoning [ Time Frame: For three years after intervention ]Cases identified by survey of local and referral hospitals and by regular interview of primary informants in each village
- Incidence of all self-poisoning [ Time Frame: For three years post-intervention ]
- Incidence of all self-harm [ Time Frame: For three years after intervention ]
- Incidence of fatal self-harm [ Time Frame: For three years post intervention ]
- Incidence of pesticide poisoning [ Time Frame: For three years post intervention ]
- Incidence of unintentional paediatric pesticide poisoning [ Time Frame: For three years post intervention ]
|Study Start Date:||December 2010|
|Study Completion Date:||June 2016|
|Primary Completion Date:||May 2013 (Final data collection date for primary outcome measure)|
Active Comparator: Storage container
Ultraviolet light resistant plastic in-ground pesticide storage container
Device: Ultraviolet light-resistant plastic in-ground pesticide storage container
In-ground pesticide storage container to be supplied to every household that uses pesticides in intervention villages
|No Intervention: Control|
We will set up a large community-based, cluster randomised controlled trial of 162 villages (mean adult population 900) in rural Sri Lanka to determine the effectiveness and cost of the provision of safe storage containers to prevent pesticide poisoning.
The study will be based in Anuradhapura District where we have carried out public health studies of pesticide poisoning since 2002. 81 intervention and 81 control villages will be recruited. Randomisation will be clustered, with villages rather than households randomised. A census will be performed at baseline and after 3 years to establish the population demographics and number of person-years exposed.
The primary outcome will be the incidence of pesticide self-poisoning; secondary outcomes will be the incidence of all self-poisoning, all self-harm, fatal self-harm, pesticide poisoning and unintentional paediatric pesticide poisoning. We will use Poisson regression models, taking account of clustering and stratification, for the analysis.
The study will provide definitive evidence concerning the cost-effectiveness of this approach that will determine whether it should be promoted across Asia.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01146496
|Mahaweli H area|
|Anuradhapura District, North Central Province, Sri Lanka|
|Principal Investigator:||Michael Eddleston||University of Edinburgh|
|Study Director:||Flemming Konradsen||University of Copenhagen|