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Trial record 44 of 138 for:    "acute promyelocytic leukemia"

Biomarkers in Bone Marrow Samples From Patients With Acute Promyelocytic Leukemia

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ClinicalTrials.gov Identifier: NCT01146223
Recruitment Status : Completed
First Posted : June 17, 2010
Last Update Posted : May 7, 2015
Sponsor:
Collaborator:
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Children's Oncology Group

Brief Summary:
This research study is studying biomarkers in patients with acute promyelocytic leukemia. Studying samples of bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and about biomarkers related to cancer.

Condition or disease Intervention/treatment
Adult Acute Myeloid Leukemia Adult Acute Myeloid Leukemia With t(15;17)(q22;q12) Adult Acute Promyelocytic Leukemia (M3) Childhood Acute Promyelocytic Leukemia (M3) Other: laboratory biomarker analysis

Detailed Description:

OBSERVATIONAL STUDY MODEL: Case-only TIME PERSPECTIVE: Retrospective BIOSPECIMEN RETENTION: Samples With DNA BIOSCPECIMEN DESCRIPTION: Bone marrow STUDY POPULATION DESCRIPTION: Primary Care Clinic SAMPLING METHOD: Non-Probability Sample

PRIMARY OBJECTIVES:

I. To measure WT1 and VEGF-1 expression in patients with acute promyelocytic leukemia.

OUTLINE: This is a multicenter study.

Patient mRNA samples from diagnosis are analyzed via quantitative PCR to measure WT1 and VEGF-1 expression.


Study Type : Observational
Actual Enrollment : 10 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Observational - WT-1's Role in Leukemogenesis
Study Start Date : September 2009
Actual Primary Completion Date : June 2011
Actual Study Completion Date : June 2011


Group/Cohort Intervention/treatment
Basic science (correlative studies)
Patient mRNA samples from diagnosis are analyzed via quantitative PCR to measure WT1 and VEGF-1 expression.
Other: laboratory biomarker analysis
Correlative studies




Primary Outcome Measures :
  1. WT1 and VEGF-1 expression [ Time Frame: Baseline ]

Biospecimen Retention:   Samples With DNA
bone marrow


Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
acute promyelocytic leukemia
Criteria

Inclusion Criteria:

  • Diagnosis of acute promyelocytic leukemia [t(15;17) translocation]
  • Not specified
  • Not specified

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01146223


Locations
United States, California
Children's Oncology Group
Monrovia, California, United States, 91006-3776
Sponsors and Collaborators
Children's Oncology Group
National Cancer Institute (NCI)
Investigators
Principal Investigator: Mustafa Moazam, MD Children's Oncology Group

Responsible Party: Children's Oncology Group
ClinicalTrials.gov Identifier: NCT01146223     History of Changes
Other Study ID Numbers: AAML10B7
NCI-2012-02717 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
CDR0000671471 ( Other Identifier: Clinical Trials.gov )
First Posted: June 17, 2010    Key Record Dates
Last Update Posted: May 7, 2015
Last Verified: May 2015

Additional relevant MeSH terms:
Leukemia
Leukemia, Myeloid
Leukemia, Myeloid, Acute
Leukemia, Promyelocytic, Acute
Neoplasms by Histologic Type
Neoplasms