Genotype-Phenotype Study of Patients With Plaquenil -Induced Retinal Toxicity, With Evaluation of the ABCA4 Gene
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|ClinicalTrials.gov Identifier: NCT01145196|
Recruitment Status : Recruiting
First Posted : June 16, 2010
Last Update Posted : May 16, 2022
- Plaquenil (hydroxychloroquine) is an anti-inflammatory drug that is used to treat some autoimmune diseases such as lupus and rheumatoid arthritis. This drug can damage the retina by causing a condition called plaquenil-induced retinal toxicity, which may lead to vision loss. However, most people taking plaquenil do not develop this problem. Researchers are interested in studying whether differences in a person s genes explain why some people develop plaquenil-induced retinal toxicity while others do not.
- To investigate possible correlations between certain genes or genetic mutations and plaquenil-induced retinal toxicity.
- Individuals at least 18 years of age who have previously used plaquenil.
- Both individuals who have and have not developed plaquenil-induced retinal toxicity will be eligible for this study.
- The study requires one or two visits to the National Eye Institute or an outpatient study clinic over a maximum 2-year period.
- Participants will provide a personal and family medical history, and will have a full eye examination.
- Participants will also provide blood samples for testing.
- No treatment will be provided as part of this protocol.
|Condition or disease|
|Genotype Retinal Disease|
The objective of this study is to investigate whether there is a correlation between genetic mutations, beginning with an analysis of ABCA4, and Plaquenil -induced retinal toxicity and to describe the phenotype of Plaquenil -induced retinal toxicity.
The study will enroll 100 patients, 18 years of age or older, found to have Plaquenil -induced retinal toxicity. 200 volunteers with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), or Sj(SqrRoot)(Delta)gren s syndrome and history of Plaquenil use, but without evidence of retinal toxicity, will also be recruited.
The study is an observational study with 1-2 outpatient visits to the NEI clinic or review of medical records for off-site participants. All participants will provide a blood sample for genetic analysis.
Clinical examination and blood samples will be used for genetic testing and mutation identification. The primary outcome of this study is to identify genetic mutations, starting with those in ABCA4 gene, associated with retinal toxicity in participants with a history of Plaquenil use. Secondary objectives i clude determining the utility of testing metrics in evaluating the presence of retinal toxicity.
|Study Type :||Observational|
|Estimated Enrollment :||300 participants|
|Official Title:||Genotype - Phenotype Study of Patients With Plaquenil-induced Retinal Toxicity|
|Actual Study Start Date :||August 23, 2010|
Participants affected by Paquenil induced retinal toxicity
control participants without Plaquenil induced retinal toxicity
- The outcome of this study is to identify genetic mutations, starting with those in ABCA4 gene, associated with retinal toxicity in participants with a history of plaquenil use. [ Time Frame: annually for five years ]The outcome of this study is to identify genetic mutations, starting with those in ABCA4 gene, associated with retinal toxicity in participants with a history of plaquenil use.
- The secondary outcome of this study is to determine the utility of various testing metrics in evaluating the presence of retinal toxicity. [ Time Frame: annually for five years ]The secondary outcome of this study is to determine the utility of various testing metrics in evaluating the presence of retinal toxicity.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01145196
|Contact: Anne M Alvarez, R.N.||(301) firstname.lastname@example.org|
|Contact: Catherine A Cukras, M.D.||(301) email@example.com|
|United States, Maryland|
|National Institutes of Health Clinical Center||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY dial 711 firstname.lastname@example.org|
|Principal Investigator:||Catherine A Cukras, M.D.||National Eye Institute (NEI)|