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Dietary Interventions for Muscle Mass

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ClinicalTrials.gov Identifier: NCT01145131
Recruitment Status : Completed
First Posted : June 16, 2010
Last Update Posted : September 14, 2011
Sponsor:
Information provided by (Responsible Party):

Study Description
Brief Summary:
Dietary intervention to prevent sarcopenia in elderly people. The objective of this study is to test whether meat structure plays an important role in protein digestion, to maximise the amino acid availability and to stimulate the muscle protein growth in elderly people.

Condition or disease Intervention/treatment
Aging Other: Intact or minced beef meat

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 12 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Dietary Interventions for Muscle Mass
Study Start Date : May 2011
Primary Completion Date : June 2011
Study Completion Date : June 2011
Arms and Interventions

Arm Intervention/treatment
Experimental: Beef steak Other: Intact or minced beef meat
135 gram piece of intact or minced beef meat, beef steak or minced beef resp.
Other Names:
  • Beef steak
  • Minced beef
  • Beef patty
  • Steak
  • Hamburger
  • Ground beef
Experimental: Minced beef Other: Intact or minced beef meat
135 gram piece of intact or minced beef meat, beef steak or minced beef resp.
Other Names:
  • Beef steak
  • Minced beef
  • Beef patty
  • Steak
  • Hamburger
  • Ground beef


Outcome Measures

Primary Outcome Measures :
  1. Muscle protein synthesis [ Time Frame: 6 h postprandial period ]
    Muscle protein synthesis will be expressed as fractional synthetic rate (FSR) by dividing the increment in enrichment in the product, i.e. protein-bound D5phe tracer, by the enrichment of the precursor (=plasma availability).


Secondary Outcome Measures :
  1. Dietary amino acid plasma availability [ Time Frame: 6h postprandial period ]
    The exogenous rate of phenylalanine appearance will be used to assess the bio-availability of dietary-protein derived amino acids in the circulation during the 6h postprandial period following meat intake


Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Non-obese male subjects (BMI<30) between the age of 65-85 years.

Exclusion Criteria:

  • Type II diabetes or other known diseases, use of medication, female, other ages or BMI than indicated above, participation in any regular exercise program.
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01145131


Locations
Netherlands
Universiteit Maastricht, Bewegingswetenschappen
Maastricht, Limburg, Netherlands, 6229ER
Sponsors and Collaborators
Maastricht University Medical Center
Investigators
Principal Investigator: B Pennings, Ir Maastricht University Medical Center