Chronic Pain Following Thoracic Surgery (PTPS-18)
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ClinicalTrials.gov Identifier: NCT01144845 |
Recruitment Status
:
Completed
First Posted
: June 16, 2010
Last Update Posted
: August 30, 2011
|
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Pain that persists after the healing of a surgical wound has previously been described as an important, but often unrecognized clinical problem. Persistent postsurgical (chronic postoperative pain) is the consequence of either ongoing inflammation or more common neuropathic pain as a result of surgical damage to peripheral nerves.
Previous studies have shown that chronic pain is a frequent and serious complication following thoracic surgery. However, the prevalence of chronic pain following both thoracoscopy and anterior thoracotomy in patients with pulmonary malignancies is poorly characterized and the impact of this pain on patients' lives remains unclear. Thus, this study aims to investigate the prevalence of chronic pain following thoracoscopy or anterior thoracotomy, and the severity and impact of persistent post-surgical pain on daily life.
This study is working with several hypotheses: 1.) persistent postsurgical pain following lung cancer surgery is predominantly of neuropathic nature and the presence of neuropathic symptoms increases the severity of postsurgical pain and reduces the patient's quality of life, 2.) the prevalence of chronic pain is reduced over time, and 3.) less invasive thoracic surgical interventions reduces the risk of the development of chronic pain.
Condition or disease | Intervention/treatment |
---|---|
Pain, Postoperative | Procedure: Thoracic surgery |
Study Type : | Observational |
Actual Enrollment : | 702 participants |
Observational Model: | Cohort |
Time Perspective: | Retrospective |
Official Title: | Study of Persistent Postsurgical Pain Following Thoracic Surgery in Patients With Pulmonary Malignancies |
Study Start Date : | April 2010 |
Actual Primary Completion Date : | June 2010 |
Actual Study Completion Date : | October 2010 |

Group/Cohort | Intervention/treatment |
---|---|
Thoracic surgical patients
Patients with pulmonary malignancies
|
Procedure: Thoracic surgery
Thoracoscopy or anterior thoracotomy
|
- Presence of persistent postsurgical pain [ Time Frame: Within 10 years after thoracic surgery ]
- Location of persistent postsurgical pain [ Time Frame: Within 10 years after thoracic surgery ]
- Duration of postsurgical pain [ Time Frame: Within 10 years after thoracic surgery ]
- Course of persistent postsurgical pain [ Time Frame: Within 10 years after thoracic surgery ]
- Severity of postsurgical pain [ Time Frame: Within 10 years after thoracic surgery ]
- Characteristics of persistent postsurgical pain [ Time Frame: Within 10 years after thoracic surgery ]
- Symptoms associated with persistent postsurgical pain [ Time Frame: Within 10 years after thoracic surgery ]
- Treatment of and effect of treatment on persistent postsurgical pain [ Time Frame: Within 10 years after thoracic surgery ]
- Effect of postsurgical pain on activity, mood, walking ability, work, interpersonal relations, sleep and quality of life [ Time Frame: Within 10 years after thoracic surgery ]

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Ages Eligible for Study: | Child, Adult, Senior |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
Inclusion Criteria:
- Patients who previously underwent thoracic surgery with lung resection from January 2000 to december 2009
Exclusion Criteria:
- Death

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01144845
Denmark | |
Department of Cardiothoracic and Vascular surgery, Aarhus University Hospital, Skejby | |
Aarhus N, Denmark, DK-8200 |
Principal Investigator: | Kasper Grosen, PhDS, MHScS, RN | Department of Cardiothoracic and Vascular surgery, Aarhus University Hospital, Skejby, Denmark | |
Study Director: | Hans K Pilegaard, MD | Department of Cardiothoracic and Vascular surgery, Aarhus University Hospital, Skejby, Denmark | |
Study Chair: | Vibeke Hjortdal, MD, Professor, DMSc, PhD | Department of Cardiothoracic and Vascular surgery, Aarhus University Hospital, Skejby, Denmark | |
Study Chair: | Mogens P Jensen, MD, PhD | Department of Rheumatology, Aarhus University Hospital, Aarhus Hospital, Denmark |
Responsible Party: | Kasper Grosen, PhD fellow, Master of Health Sciences, RN, University of Aarhus |
ClinicalTrials.gov Identifier: | NCT01144845 History of Changes |
Other Study ID Numbers: |
PTPS-18 |
First Posted: | June 16, 2010 Key Record Dates |
Last Update Posted: | August 30, 2011 |
Last Verified: | August 2011 |
Keywords provided by Kasper Grosen, University of Aarhus:
Thoracotomy Thoracic Surgery Thoracic Surgical Procedures |
Thoracic Surgery, Video-Assisted Lung Neoplasms Thoracic Nerves |
Additional relevant MeSH terms:
Pain, Postoperative Pain Neurologic Manifestations Nervous System Diseases |
Postoperative Complications Pathologic Processes Signs and Symptoms |