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Amino Acid Profile in the Fetus and the Neonate

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2010 by Sheba Medical Center.
Recruitment status was:  Not yet recruiting
Information provided by:
Sheba Medical Center Identifier:
First received: June 8, 2010
Last updated: NA
Last verified: June 2010
History: No changes posted

Up-to-date, the preterm newborn nutrition is based on human breast milk or it's imitations. However, the growth rate is known to be reduced compared to the fetal growth rate. In order to attempt a better growth rate of the preterm newborn infants it is important to evaluate the metabolic components of the fetal blood and try to find components that might influence its growth.

Little is known of the metabolic components of the fetal blood, including amino acid profile. The aim of the study is to evaluate amino acid profile in the fetus blood in different gestational ages and compare it to post natal period.

Condition Intervention
Cord Blood Amino Acid Profile
Fetal Amino Acid Profile in Different Gestational Ages
Infant Amino Acid Profile at Day 3 and Discharge
Other: Blood sample on Guthrie paper from cord blood, and day 3 of life and before discharge

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective

Further study details as provided by Sheba Medical Center:

Estimated Enrollment: 180
Study Start Date: July 2010
Groups/Cohorts Assigned Interventions
Term and preterm newborn infants
5 infants of each gestational age of 24-42 weeks
Other: Blood sample on Guthrie paper from cord blood, and day 3 of life and before discharge
Mass spectroscopy on the blood sample that are taken as routine for the national inborn errors survey


Ages Eligible for Study:   up to 6 Months   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Term and preterm newborn infants

Inclusion Criteria:

  • All new-born infants 5 of each gestational age

Exclusion Criteria:

  Contacts and Locations
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Please refer to this study by its identifier: NCT01140698

Contact: Leah Leibovitch, MD 972-52-6667325

Sheba medical center Not yet recruiting
Ramat Gan, Israel, 52621
Contact: Leah Leibovitch, MD    972-52-6667325   
Principal Investigator: Leah Leibovitch, MD         
Sponsors and Collaborators
Sheba Medical Center
  More Information

Responsible Party: Leah Leibovitch, Shaba Medical Center Identifier: NCT01140698     History of Changes
Other Study ID Numbers: SHEBA-10-7895-LL-SMC
Study First Received: June 8, 2010
Last Updated: June 8, 2010 processed this record on May 25, 2017