Proteomic Analysis Reveals Innate Immune Activity In Intestinal Transplant Dysfunction
Many patients with intestinal failure require intestinal transplantation for survival. Currently, the gold standard for diagnosing acute cellular rejection (ACR) is histological examination of endoscopic biopsies, which are taken invasively and lack sensitivity. A non-invasive method of monitoring for ACR is needed.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Proteomic Analysis Reveals Innate Immune Activity In Intestinal Transplant Dysfunction|
- Evaluate levels of proteins and cytokines in ostomy effluent during episodes of rejection [ Time Frame: first 8 weeks post transplant ] [ Designated as safety issue: No ]
Protocol biopsies of the transplanted intestine are obtained during endoscopy and when clinical symptoms indicating abnormal allograft function are present. Biopsies were sent to pathology, where the pathologist determined if there was acute rejection.
Ostomy effluent taken during times of endoscopy were subjected to MALDI and Luminex technology to look for any proteins or cytokines differentially expressed during rejection.
Biospecimen Retention: Samples With DNA
|Study Start Date:||July 2008|
|Study Completion Date:||September 2009|
|Primary Completion Date:||September 2009 (Final data collection date for primary outcome measure)|
Intestinal transplant recipients with no evidence of biopsy proven rejection
Intestinal transplant recipients who had evidence of biopsy proven rejection
Show Detailed Description
Please refer to this study by its ClinicalTrials.gov identifier: NCT01140152
|United States, California|
|Los Angeles, California, United States, 90095|
|Principal Investigator:||Anjuli R Kumar, M.D.||University of California, Los Angeles|