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A Comparative Study of Depth of Anesthesia Monitored by Bispectral Index (BIS) Values

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01140100
First Posted: June 9, 2010
Last Update Posted: June 9, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Shiraz University of Medical Sciences
  Purpose
The aim of this study is to determine whether induction of anesthesia with thiopental followed by propofol infusion is able to maintain sufficient depth of anesthesia .

Condition Intervention Phase
Anesthetics Drug: propofol Drug: thiopental,propofol Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Comparative Study of Depth of Anesthesia Monitored by BIS Values in Two Anesthesia Techniques

Resource links provided by NLM:


Further study details as provided by Shiraz University of Medical Sciences:

Enrollment: 82
Arms Assigned Interventions
Active Comparator: propofol-propofol Drug: propofol
Experimental: thiopental-propofol Drug: thiopental,propofol

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • being adult
  • having ASA I or II
  • scheduled for elective cataract surgery under general anesthesia

Exclusion Criteria:

  • massive obesity
  • intake of any central nervous system (CNS) stimulants
  • intake of CNS depressants
  • intake of Tricyclic antidepressants
  • known adverse reaction to the study drugs
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01140100


Locations
Iran, Islamic Republic of
Shiraz University of Medical Sciences
Shiraz, Fars, Iran, Islamic Republic of
Sponsors and Collaborators
Shiraz University of Medical Sciences
Investigators
Principal Investigator: Sina Ghaffaripour, M.D Shiraz University of Medical Sciences
Study Director: Hilda Mahmoudi, M.D Shiraz University of Medical Sciences
  More Information

ClinicalTrials.gov Identifier: NCT01140100     History of Changes
Other Study ID Numbers: 85-3211
First Submitted: June 8, 2010
First Posted: June 9, 2010
Last Update Posted: June 9, 2010
Last Verified: January 2007

Additional relevant MeSH terms:
Propofol
Thiopental
Hypnotics and Sedatives
Central Nervous System Depressants
Physiological Effects of Drugs
Anesthetics, Intravenous
Anesthetics, General
Anesthetics
Anticonvulsants
GABA Modulators
GABA Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action