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A Comparative Study of Depth of Anesthesia Monitored by Bispectral Index (BIS) Values

This study has been completed.
Information provided by:
Shiraz University of Medical Sciences Identifier:
First received: June 8, 2010
Last updated: NA
Last verified: January 2007
History: No changes posted
The aim of this study is to determine whether induction of anesthesia with thiopental followed by propofol infusion is able to maintain sufficient depth of anesthesia .

Condition Intervention Phase
Drug: propofol
Drug: thiopental,propofol
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Comparative Study of Depth of Anesthesia Monitored by BIS Values in Two Anesthesia Techniques

Resource links provided by NLM:

Further study details as provided by Shiraz University of Medical Sciences:

Enrollment: 82
Arms Assigned Interventions
Active Comparator: propofol-propofol Drug: propofol
Experimental: thiopental-propofol Drug: thiopental,propofol


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • being adult
  • having ASA I or II
  • scheduled for elective cataract surgery under general anesthesia

Exclusion Criteria:

  • massive obesity
  • intake of any central nervous system (CNS) stimulants
  • intake of CNS depressants
  • intake of Tricyclic antidepressants
  • known adverse reaction to the study drugs
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Please refer to this study by its identifier: NCT01140100

Iran, Islamic Republic of
Shiraz University of Medical Sciences
Shiraz, Fars, Iran, Islamic Republic of
Sponsors and Collaborators
Shiraz University of Medical Sciences
Principal Investigator: Sina Ghaffaripour, M.D Shiraz University of Medical Sciences
Study Director: Hilda Mahmoudi, M.D Shiraz University of Medical Sciences
  More Information Identifier: NCT01140100     History of Changes
Other Study ID Numbers: 85-3211
Study First Received: June 8, 2010
Last Updated: June 8, 2010

Additional relevant MeSH terms:
Hypnotics and Sedatives
Central Nervous System Depressants
Physiological Effects of Drugs
Anesthetics, Intravenous
Anesthetics, General
GABA Modulators
GABA Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action processed this record on May 25, 2017