Association Between Framingham Risk Score, hsCRP and Vascular Inflammation: Analysis With 18F-Fluorodeoxyglucose Positron Emission Tomography
Framingham risk score is well known screening tool that detect cardiovascular (CV) risk. But it is not suitable for CV risk in mild risk group. So 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is a new imaging technique for detecting vascular inflammation within atherosclerotic plaques and hsCRP is also arising detection tool of CV risk.
The investigators are examining this association in normal and impaired glucose tolerance patients groups.
|Study Design:||Observational Model: Cohort
Time Perspective: Cross-Sectional
|Study Start Date:||September 2009|
|Study Completion Date:||February 2010|
|Primary Completion Date:||February 2010 (Final data collection date for primary outcome measure)|
normal group has no diabetes.
IGT group has impaired fasting glucose or impaired glucose tolerance.
We examined vascular inflammation using FDG-PET scan in 178 subjects (Normal and impaired glucose tolerance groups). Vascular 18F-FDG uptake was measured as both the mean and maximum blood-normalized standardized uptake value (SUV), known as the target-to-background ratio (TBR). And We analyzed that the association with Framingham risk score, hs CRP and vascular inflammation by FDG-PET scan.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01139827
|Korea, Republic of|
|Korea university guro hospital|
|Seoul, Korea, Republic of|