Blood and Tumor Tissue Samples From Young Patients With Acute Myeloid Leukemia

This study is ongoing, but not recruiting participants.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Children's Oncology Group
ClinicalTrials.gov Identifier:
NCT01139333
First received: June 5, 2010
Last updated: May 6, 2015
Last verified: May 2015
  Purpose

RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research study is studying blood and tumor tissue samples from young patients with acute myeloid leukemia.


Condition Intervention
Leukemia
Genetic: gene expression analysis
Genetic: western blotting
Other: flow cytometry
Other: laboratory biomarker analysis

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Evaluation of Mer and Axl Expression in Acute Myeloid Leukemia Patient Samples

Resource links provided by NLM:


Further study details as provided by Children's Oncology Group:

Primary Outcome Measures:
  • Expression of Mer and Axl [ Designated as safety issue: No ]
  • Association of abnormal expression of Mer and Axl with induction failure or relapse [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA

blood and tumor samples


Estimated Enrollment: 52
Study Start Date: September 2009
Estimated Primary Completion Date: January 2100 (Final data collection date for primary outcome measure)
Detailed Description:

OBJECTIVES:

  • To evaluate Mer and Axl expression in samples from pediatric patients with acute myeloid leukemia (AML).
  • To determine if abnormal expression of Mer and Axl is associated with poor clinical characteristics (e.g., induction failure or relapse) of AML in these patients.

OUTLINE: This is a multicenter study.

Archived samples from pediatric patients with acute myeloid leukemia are analyzed for Mer and Axl expression by flow cytometry and western blot assays.

  Eligibility

Ages Eligible for Study:   up to 17 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Diagnosis of acute myeloid leukemia

Criteria

DISEASE CHARACTERISTICS:

  • Diagnosis of acute myeloid leukemia
  • Children Oncology Group (COG) patient samples

PATIENT CHARACTERISTICS:

  • Available clinical data

PRIOR CONCURRENT THERAPY:

  • Not specified
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01139333

Sponsors and Collaborators
Children's Oncology Group
Investigators
Principal Investigator: Kristen M. Eisenman, MD University of Colorado, Denver
  More Information

Additional Information:
No publications provided

Responsible Party: Children's Oncology Group
ClinicalTrials.gov Identifier: NCT01139333     History of Changes
Other Study ID Numbers: AAML10B4, COG-AAML10B4, CDR0000671452, NCI-2011-02222
Study First Received: June 5, 2010
Last Updated: May 6, 2015
Health Authority: United States: Federal Government

Keywords provided by Children's Oncology Group:
childhood acute myeloid leukemia/other myeloid malignancies

Additional relevant MeSH terms:
Leukemia
Leukemia, Myeloid
Leukemia, Myeloid, Acute
Neoplasms
Neoplasms by Histologic Type

ClinicalTrials.gov processed this record on May 27, 2015