Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Role of Endothelial Function, Muscular Fitness and Metabolism in Functional Activity in Patients With Chronic Heart Failure (CHF)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2010 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
Information provided by:
National Taiwan University Hospital Identifier:
First received: June 7, 2010
Last updated: NA
Last verified: June 2010
History: No changes posted

Shortness of breath, fatigue, and exercise intolerance are clinical symptoms of chronic heart failure (CHF). Recent studies suggested that peripheral impairment was the major cause of clinical symptoms, and mechanism may be related to neuroendocrine impairment and vascular smooth muscle dysfunction. It results in increased peripheral resistance that may influence limb blood flow, muscle fitness and activities of daily.The purposes of this study are

  1. to compare muscular strength, endurance, and perfusion of quadriceps between CHF patients and healthy controls by isokinetic test and near-infrared spectroscopy (NIRS) and difference in activities of daily living
  2. to compare endothelium function between CHF patients and healthy control subjects
  3. the relationship between endothelium function, muscular strength, endurance, perfusion, and metabolism of quadriceps.

Chronic Heart Failure
Coronary Disease
Dilated Cardiomyopathy

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Role of Endothelial Function, Muscular Fitness and Metabolism in Functional Activity in Patients With Chronic Heart Failure

Resource links provided by NLM:

Further study details as provided by National Taiwan University Hospital:

Primary Outcome Measures:
  • muscle strength and endurance [ Time Frame: baseline ]
    Measured by biodex

Secondary Outcome Measures:
  • skeletal muscle oxygenation response [ Time Frame: baseline ]
    Measured by near-infrared spectroscopy

  • Walking distance in 6-minute walking test [ Time Frame: baseline ]
    walking distance (m)

  • laser Doppler flowmetry combine iontophoresis [ Time Frame: baseline ]
    To measure the blood flux (PU) response to Ach (endothelial-dependent agent) and SNP (endothelial-independent agent)

  • sit-to-stand test [ Time Frame: baseline ]
    Measured times in 1 minute

  • questionnaire (functional activity and quality of life) [ Time Frame: baseline ]
  • Analysis of venous blood sample [ Time Frame: baseline ]
    By standard venipuncture

Estimated Enrollment: 100
Study Start Date: May 2010
Estimated Study Completion Date: May 2011
Estimated Primary Completion Date: May 2011 (Final data collection date for primary outcome measure)
Cardiovascular disease
Diagnosis of cardiomyopathy or ischemic heart disease without heart failure
Chronic heart failure
Diagnosis of cardiomyopathy or ischemic heart disease LVEF <40%
Age and body built matched with chronic heart failure group


Ages Eligible for Study:   40 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Chronic Heart Failure Coronary Disease Dilated Cardiomyopathy Control group without diagnosis of any heart disease

Inclusion Criteria:

  • Age 40-75 years
  • Chronic heart failure: ejection fraction<40% and at stable condition
  • Coronary Disease and dilated cardiomyopathy without heart failure
  • Control group without diagnosis of any heart disease

Exclusion Criteria:

  • Clinical diagnosis of neuromusculoskeletal , pulmonary, or other systemic diseases that may affect the testing of the study
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01139086

Contact: Ying-Tai Wu, Ph.D +886-2-33668129

National Taiwan University Hospital Recruiting
Taipei City, Taiwan, 100
Contact: Ying-Tai Wu, Ph. D    886-2-33668129   
Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: Ying-Tai Wu, Ph.D National Taiwan University Hospital
  More Information

Responsible Party: Ying-Tai Wu, School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University Identifier: NCT01139086     History of Changes
Other Study ID Numbers: 201003050R
Study First Received: June 7, 2010
Last Updated: June 7, 2010

Keywords provided by National Taiwan University Hospital:
chronic heart failure
isokinetic test
near-infrared spectroscopy
laser Doppler flowmetry
endothelial function

Additional relevant MeSH terms:
Heart Failure
Coronary Disease
Coronary Artery Disease
Cardiomyopathy, Dilated
Heart Diseases
Cardiovascular Diseases
Myocardial Ischemia
Vascular Diseases
Arterial Occlusive Diseases
Cardiomegaly processed this record on May 22, 2017