Control of MRSA in Nursing Homes: Decolonization vs Standard Precautions
The purpose of this study is to determine the better approach between the currently procedure (i.e. standards precautions) and a reinforced strategy to control MRSA transmission in the institutionalized population of nursing homes in Canton of Vaud, Switzerland.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention
|Official Title:||Universal Screening and Decolonization vs Standard Precautions for Control of Methicillin-resistant Staphylococcus Aureus (MRSA) in Nursing Homes: a Cluster, Randomised Controlled Study.|
- To determine the change in prevalence of MRSA carriage among residents of each Nursing homes group at the end of the one study year [ Time Frame: 1 year ] [ Designated as safety issue: No ]in each control and intervention nursing home: MRSA screening of all residents of nursing homes of Canton Vaud, at baseline and 1 year later, in order to compare MRSA prevalence changes at nursing homes levels
- To determine the effectiveness of the reinforced strategy to prevent MRSA infection, compared to the standard strategy [ Time Frame: 1 year ] [ Designated as safety issue: No ]In a subpopulation of all nursing homes residents (10% of the whole population), recording of all microbiologically documented MRSA infection, according to nosocomial infection definitions of the Center of Diseases Control (CDC) of Atlanta.
|Study Start Date:||June 2010|
|Study Completion Date:||December 2011|
|Primary Completion Date:||December 2011 (Final data collection date for primary outcome measure)|
No Intervention: Standard Precautions
control arm, standards precautions for all residents living in the nursing home of control arm, including MRSA carriers
Intervention arm, standards precautions for all residents living in nursing homes of intervention arm, and topical decolonization for MRSA carriers, including environmental disinfection
5 days topical decolonisation including nasal mupirocin tid, chlorhexidine mouth wash tid, chlorhexidine body wash once daily.
Daily direct resident's environmental disinfection during decolonisation.
Other Name: topical MRSA decolonisation and environmental disinfection
MRSA carriage among nursing homes residents of Canton Vaud, Switzerland, is increasing, despite use of standard precautions. Recommendation to prevent MRSA transmission in long term care facilities are lacking. We aim to reinforce the current infection control strategy by general MRSA screening of institutionalised residents and decolonisation of MRSA carriers. Because the uncertainties in the impact of this reinforced strategy, we aim to compare this action to the policy actually applied.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01138462
|all nursing homes of canton Vaud|
|Canton de Vaud, Canton Vaud, Switzerland|
|Study Director:||Giorgio Zanetti, MD||University Hospital of Lausanne, Switzerland|