Biomarkers in Young Patients With Acute Myeloid Leukemia
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|ClinicalTrials.gov Identifier: NCT01138332|
Recruitment Status : Completed
First Posted : June 7, 2010
Last Update Posted : May 6, 2015
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about biomarkers related to cancer.
PURPOSE: This research study is studying biomarkers in tissue samples from young patients with acute myeloid leukemia.
|Condition or disease||Intervention/treatment|
|Leukemia||Genetic: western blotting Other: laboratory biomarker analysis|
- Determine the frequency of ligand-independent phosphorylation of Stat3 in a small cohort of samples from pediatric patients with acute myeloid leukemia including, but not limited to, samples known to express mutated c-kit.
- Measure the level of Stat3 phosphorylation in these samples after stimulation of three key cytokine receptors expressed on hematopoietic cells IL-6R, G-CSFR, and c-kit.
OUTLINE: Cryopreserved samples are analyzed for levels of various components of the Stat3 pathway via western blotting.
|Study Type :||Observational|
|Actual Enrollment :||20 participants|
|Official Title:||Stat3 Signaling Pathway Aberrancies in Pediatric AML|
|Study Start Date :||September 2009|
|Actual Primary Completion Date :||March 2010|
|Actual Study Completion Date :||March 2010|
- Correlations between levels of pY-Stat3 and levels of upstream cytokine receptors
- Association of constitutive and/or increased pY-Stat3 and c-kit genotype
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01138332
|Principal Investigator:||Michele S. Redell, MD, PhD||Texas Children's Cancer Center|