Biomarkers in Patients With Acute Myeloid Leukemia
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is studying biomarkers in patients with acute myeloid leukemia.
Genetic: DNA analysis
Genetic: mutation analysis
Genetic: polymerase chain reaction
Other: laboratory biomarker analysis
|Study Design:||Observational Model: Case-Only
Time Perspective: Retrospective
|Official Title:||Mitochondrial Mutations and AML|
- Association between clonally expanded somatic mitochondrial DNA mutations and acute myeloid leukemia [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
|Study Start Date:||February 2009|
|Primary Completion Date:||March 2010 (Final data collection date for primary outcome measure)|
- To determine whether clonally expanded somatic mitochondrial DNA mutations are associated with acute myeloid leukemia.
OUTLINE: Genomic DNA from blood samples obtained at diagnosis, remission, and relapse are analyzed for mitochondrial DNA mutations via PCR.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01138319
|Principal Investigator:||Jason H. Bielas, PhD||Fred Hutchinson Cancer Research Center|