Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Biomarkers in Patients With Acute Myeloid Leukemia

This study has been completed.
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Children's Oncology Group Identifier:
First received: June 4, 2010
Last updated: May 5, 2015
Last verified: May 2015

RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research study is studying biomarkers in patients with acute myeloid leukemia.

Condition Intervention
Genetic: DNA analysis
Genetic: mutation analysis
Genetic: polymerase chain reaction
Other: laboratory biomarker analysis

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Mitochondrial Mutations and AML

Resource links provided by NLM:

Further study details as provided by Children's Oncology Group:

Primary Outcome Measures:
  • Association between clonally expanded somatic mitochondrial DNA mutations and acute myeloid leukemia

Biospecimen Retention:   Samples With DNA
blood samples

Enrollment: 18
Study Start Date: February 2009
Primary Completion Date: March 2010 (Final data collection date for primary outcome measure)
Detailed Description:


  • To determine whether clonally expanded somatic mitochondrial DNA mutations are associated with acute myeloid leukemia.

OUTLINE: Genomic DNA from blood samples obtained at diagnosis, remission, and relapse are analyzed for mitochondrial DNA mutations via PCR.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Diagnosis of acute myeloid leukemia


  • Diagnosis of acute myeloid leukemia
  • Available blood samples from diagnosis, remission, and relapse


  • Not specified


  • Not specified
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01138319

Sponsors and Collaborators
Children's Oncology Group
National Cancer Institute (NCI)
Principal Investigator: Jason H. Bielas, PhD Fred Hutchinson Cancer Research Center
  More Information

Responsible Party: Children's Oncology Group Identifier: NCT01138319     History of Changes
Other Study ID Numbers: AAML10B6
COG-AAML10B6 ( Other Identifier: Children's Oncology Group )
CDR0000671467 ( Other Identifier: Clinical )
NCI-2011-02224 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
Study First Received: June 4, 2010
Last Updated: May 5, 2015

Keywords provided by Children's Oncology Group:
adult acute myeloid leukemia
childhood acute myeloid leukemia/other myeloid malignancies

Additional relevant MeSH terms:
Leukemia, Myeloid
Leukemia, Myeloid, Acute
Neoplasms by Histologic Type
Neoplasms processed this record on May 23, 2017