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T-Wave Alternans in Patients With Suspected Acute Coronary Syndrome (TWA)

This study has been completed.
Information provided by (Responsible Party):
Loma Linda University Identifier:
First received: June 3, 2010
Last updated: May 22, 2014
Last verified: May 2014
The purpose of this study is to measure T-Wave Alternans (TWA) in patients with acute coronary syndrome. Researchers are blinded to clinical TWA measurements. The investigators will then try to determine if T-Wave alternans correlates with clinical outcome of patients with Acute Coronary Syndrome. During routine care of the patient, the T Wave Alternans is measured.

Condition Intervention
Chest Pain Acute Coronary Syndrome Acute Myocardial Infarction Device: Observational Measurement of T-wave Alternans Device: T-wave Alternans

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: T-Wave Alternans in Patients Acute Coronary Syndrome

Resource links provided by NLM:

Further study details as provided by Loma Linda University:

Primary Outcome Measures:
  • correlation of T-Wave Alternans with Acute myocardial Ischemia [ Time Frame: 6 month ]
    We hope to correlate the Twave Alternans with Acute Myocardial Ischemia. Most importantly we are trying to create a sensitive measure of acute myocardial Ischemia or a rule out study.

Enrollment: 252
Study Start Date: July 2010
Study Completion Date: December 2013
Primary Completion Date: December 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Chest Pain
Acute Myocardial ischemia
Device: Observational Measurement of T-wave Alternans
Measurement is similar to typical EKG
Device: T-wave Alternans
T-Wave Alternans will be measured in an observational fashion

  Show Detailed Description


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
18-100 Pt presenting with Chest Pain

Inclusion Criteria:

  • Adults with Acute Chest Pain

Exclusion Criteria:

  • Patients with underlying myoclonic tremors making measurement artifact unreliable
  • Less than 18 years of age
  • Skin disorders that do not allow the Cardiac Monitor Leads to adhere to the skin
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01137513

United States, California
Loma Linda University
Loma Linda, California, United States, 92562
Sponsors and Collaborators
Loma Linda University
  More Information

Responsible Party: Loma Linda University Identifier: NCT01137513     History of Changes
Other Study ID Numbers: RS-49780
Study First Received: June 3, 2010
Last Updated: May 22, 2014

Keywords provided by Loma Linda University:
Chest Pain
Acute coronary syndrome

Additional relevant MeSH terms:
Myocardial Infarction
Acute Coronary Syndrome
Chest Pain
Pathologic Processes
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms processed this record on September 21, 2017