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The Impact of Vitamin D on Tuberculosis Among Koreans

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ClinicalTrials.gov Identifier: NCT01137370
Recruitment Status : Completed
First Posted : June 4, 2010
Results First Posted : February 24, 2014
Last Update Posted : February 24, 2014
Sponsor:
Information provided by (Responsible Party):
Jae-Joon Yim, Seoul National University Hospital

Brief Summary:
Vitamin D has been regarded to be beneficial to tuberculosis (TB) patients. The aim of this study is to elucidate the role of vitamin D deficiency in development and treatment outcomes among Korean TB patients. Furthermore, the impact of genotypes of vitamin D receptor gene on TB development will also be evaluated.

Condition or disease
Tuberculosis

Study Type : Observational
Actual Enrollment : 203 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Impact of Vitamin D Level and Single Nucleotide Polymorphisms of Vitamin D Receptor Gene on the Development and Treatment Response of Tuberculosis
Study Start Date : January 2010
Actual Primary Completion Date : March 2011
Actual Study Completion Date : April 2011

Resource links provided by the National Library of Medicine

Drug Information available for: Vitamin D

Group/Cohort
Patients with TB
People without TB



Primary Outcome Measures :
  1. Prevalence of Vitamin D Deficiency [ Time Frame: At enrollment ]
  2. Median 25-OHD Level [ Time Frame: August 2010 to March 2011 ]

Biospecimen Retention:   Samples With DNA
Serums for vitamin D measurement DNA for genotyping of vitamin D receptor gene


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Ages Eligible for Study:   20 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Patients diagnosed and treated as having a TB in Seoul National University Hospital
Criteria

Inclusion Criteria:

  • older than 19 years
  • diagnosed and treated having a tuberculosis

Exclusion Criteria:

  • positive HIV antibody

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01137370


Locations
Korea, Republic of
Seoul National University Hospital
Seoul, Korea, Republic of, 110-744
Sponsors and Collaborators
Seoul National University Hospital

Responsible Party: Jae-Joon Yim, Professor, Seoul National University Hospital
ClinicalTrials.gov Identifier: NCT01137370     History of Changes
Other Study ID Numbers: H-0911-066-301
First Posted: June 4, 2010    Key Record Dates
Results First Posted: February 24, 2014
Last Update Posted: February 24, 2014
Last Verified: January 2014

Additional relevant MeSH terms:
Tuberculosis
Mycobacterium Infections
Actinomycetales Infections
Gram-Positive Bacterial Infections
Bacterial Infections
Vitamins
Vitamin D
Micronutrients
Growth Substances
Physiological Effects of Drugs
Bone Density Conservation Agents