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Assessment of the Sympathetic Nervous System Blockade of the Upper Limb After a Brachial Plexus Block in Patients With End Stage Renal Failure

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ClinicalTrials.gov Identifier: NCT01135979
Recruitment Status : Withdrawn (Unable to recruit)
First Posted : June 3, 2010
Last Update Posted : March 6, 2013
Sponsor:
Information provided by (Responsible Party):
University of Nottingham

Brief Summary:
The purpose of this study is to investigate what effect a local anesthetic nerve block of the arm in patients with end stage renal failure has upon blood flow in the skin of the arm.

Condition or disease
Renal Failure

Detailed Description:

Aim

To quantify the degree of sympathetic blockade in the upper limb in patients with end stage renal failure produced during a regional anaesthetic technique, using laser Doppler flowmetry.

Hypothesis

Regional anaesthesia of the upper limb results in blockade of motor and sensory nerves, providing surgical and post-operative analgesia. Sympathetic nerves are also blocked resulting in local vasodilatation. This may be of benefit in surgery where enhanced blood flow is beneficial such as arterio-venous fistula creation. The degree and duration of sympathetic blockade produced by regional blocks however, has never been quantified. This study aims to quantify sympathetic blockade by measuring the changes in skin blood flow and skin temperature after placement of a brachial plexus block.


Study Type : Observational
Actual Enrollment : 0 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Assessment of the Sympathetic Nervous System Blockade of the Upper Limb After a Brachial Plexus Block in Patients With End Stage Renal Failure
Study Start Date : February 2010
Estimated Primary Completion Date : December 2012
Estimated Study Completion Date : December 2012

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Kidney Failure

Group/Cohort
Arterio-venous fistulae creation




Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with end stage renal failure who are due to have a forearm fistula created
Criteria

Inclusion Criteria:

  • Patients with end stage renal failure
  • Over 18 years of age
  • Written consent obtained
  • Due to undergo surgery for forearm fistula creation under a regional block

Exclusion Criteria:

  • Smokers
  • Damaged skin on the arm
  • Circulatory disorders such as Raynaud's disease, systemic sclerosis, sickle cell trait or disease
  • Current use of beta blockers
  • undergoing haemodialysis for more than 12 months

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01135979


Locations
United Kingdom
Nottingham University Hospitals NHS Trust
Nottingham, Nottinghamshire, United Kingdom, NG7 2UH
Sponsors and Collaborators
University of Nottingham

Responsible Party: University of Nottingham
ClinicalTrials.gov Identifier: NCT01135979     History of Changes
Other Study ID Numbers: 07AN007
First Posted: June 3, 2010    Key Record Dates
Last Update Posted: March 6, 2013
Last Verified: March 2013

Additional relevant MeSH terms:
Renal Insufficiency
Kidney Failure, Chronic
Kidney Diseases
Urologic Diseases
Renal Insufficiency, Chronic