Functional Magnetic Resonance Imaging (MRI) of Hypnosis and Mindfulness Meditation
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|ClinicalTrials.gov Identifier: NCT01135810|
Recruitment Status : Completed
First Posted : June 3, 2010
Last Update Posted : December 3, 2013
|Condition or disease||Intervention/treatment|
|Hypnosis||Behavioral: Hypnosis Behavioral: Meditation|
Our goal is to determine the functional brain networks that define and distinguish two induced states of sustained attention -- hypnosis and mindfulness -- that may be of substantial relevance to medicine.
Defining the neural underpinnings of these states would have broad implications for understanding how cognitive states emerge from functional networks, how they affect peripheral autonomic nervous system activity, and how their therapeutic efficacy can be optimized.
We propose a functional MRI study using resting state methodology to study 20-40 subjects from each of the four following groups:
- Highly hypnotizable subjects
- Minimally hypnotizable subjects
- Experienced mindfulness meditators
- Novice mindfulness meditators. The ability to be hypnotized is a stable and measurable trait that can be pre-screened and quantified. Dr. Spiegel will select subjects according to their ability to be hypnotized prior to the MRI visit (see ?recruiting? below). We will seek greatest contrast between groups by enrolling those with the highest (8-10) and lowest (0-2) scores on the Hypnotic Induction Profile. The presence of a poorly hypnotizable group allows for a control condition of those who have undergone an identical induction routine without achieving hypnotic trance. Similarly, novice meditators will serve as a control for the group experienced in mindfulness meditation.
Prior studies have shown differences in both brain activation and grey matter volume associated with longer practice of meditation (> 4 years) compared with novice meditators. As such, experienced meditators will be defined as those with a regular meditation practice of four years or longer. Novice meditators will be new practitioners who are interested in mindfulness meditation practice, and who completed a one-hour meditation training during the week before their study participation.
|Study Type :||Observational|
|Actual Enrollment :||102 participants|
|Observational Model:||Case Control|
|Official Title:||Resting State Functional MRI Investigation of Hypnotic Trance and Mindfulness Meditation|
|Study Start Date :||September 2009|
|Actual Primary Completion Date :||September 2011|
|Actual Study Completion Date :||September 2011|
- MRI scan: brain activity [ Time Frame: 1 hour ]
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01135810
|United States, California|
|Stanford University School of Medicine|
|Stanford, California, United States, 94305|
|Principal Investigator:||David Spiegel||Stanford University|