Physiologic Evaluation of Anomalous Right Coronary Artery Stenosis

This study has been completed.
Information provided by (Responsible Party):
Bon-Kwon Koo, Seoul National University Hospital Identifier:
First received: May 26, 2010
Last updated: December 1, 2013
Last verified: December 2013

The anomalous origin of right coronary artery (RCA) is a rare coronary anomaly. Recently, the detection of this anomaly has been more frequent as the use of cardiac multidetector computed tomography has become more popular. It can cause myocardial ischemia, syncope and sudden cardiac death. Surgical repair is generally recommended for symptomatic patients. However, there is controversy concerning the proper evaluation and treatment strategy for patients without documented myocardial ischemia.

The stenotic lesion of anomalous origin of RCA will be assessed by fractional flow reserve (FFR).

Condition Intervention Phase
Coronary Vessel Anomalies
Procedure: revascularization
Phase 4

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Physiologic Evaluation of Anomalous Right Coronary Artery Stenosis

Further study details as provided by Seoul National University Hospital:

Primary Outcome Measures:
  • cardiac death [ Time Frame: 12 months ] [ Designated as safety issue: No ]

Enrollment: 36
Study Start Date: August 2009
Study Completion Date: December 2013
Primary Completion Date: December 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: low FFR
Procedure: revascularization
surgery or stenting
Other Name: other names are not available
No Intervention: high FFR
FFR > 0.75


Ages Eligible for Study:   20 Years to 85 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • patients diagnosed as anomalous origin of right coronary artery from left coronary cusp

Exclusion Criteria:

  • poor compliance
  • need for percutaneous coronary intervention to significant coronary lesion
  • failure of FFR for anomalous origin of right coronary artery
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Please refer to this study by its identifier: NCT01133054

Korea, Republic of
Seoul National University Hospital
Seoul, Korea, Republic of, 110-744
Sponsors and Collaborators
Seoul National University Hospital
Study Chair: Bon-Kwon KOO, M.D. Seoul National University Hospital
  More Information

Responsible Party: Bon-Kwon Koo, Associate professor, Seoul National University Hospital Identifier: NCT01133054     History of Changes
Other Study ID Numbers: D-0908-010-060 
Study First Received: May 26, 2010
Last Updated: December 1, 2013
Health Authority: Korea: Food and Drug Administration

Keywords provided by Seoul National University Hospital:
Coronary Vessel Anomalies

Additional relevant MeSH terms:
Coronary Stenosis
Coronary Vessel Anomalies
Cardiovascular Abnormalities
Cardiovascular Diseases
Congenital Abnormalities
Coronary Disease
Heart Defects, Congenital
Heart Diseases
Myocardial Ischemia
Vascular Diseases processed this record on May 26, 2016