Sleep, Breathing and Psychomotor Performance at Altitude: A Physiologic Study in Healthy Subjects
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ClinicalTrials.gov Identifier: NCT01130948 |
Recruitment Status :
Completed
First Posted : May 26, 2010
Last Update Posted : May 20, 2014
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Healthy Men | Other: altitude exposure | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 51 participants |
Allocation: | Randomized |
Intervention Model: | Crossover Assignment |
Masking: | Single (Outcomes Assessor) |
Official Title: | Sleep, Breathing and Psychomotor Performance at Altitude: A Physiologic Study in Healthy Subjects |
Study Start Date : | May 2010 |
Actual Primary Completion Date : | October 2010 |
Actual Study Completion Date : | October 2010 |
- Other: altitude exposure
exposure to 490m, 1700m and 2590m
- apnea/hypopnea index [ Time Frame: day 1-4 at altitude ]
- Reaction time [ Time Frame: day 1-4 at altitude ]psychomotor vigilance test reaction time
- Psychomotor vigilance [ Time Frame: day 1-4 at altitude ]performance in the Motor Task Manager test
- sleep quality [ Time Frame: day 1-4 at altitude ]percent of slow wave sleep, araousal index
- arterial applanation tonometry [ Time Frame: day 1-4 at altitude ]endothelial function and arterial stiffness

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Ages Eligible for Study: | 18 Years to 70 Years (Adult, Older Adult) |
Sexes Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- healthy men
- residence at <800m
Exclusion Criteria:
- any active disease requiring treatment
- requirement for regular use of medication
- smoking, regular intake of alcohol or drugs
- body mass index <18 or >30 kg/m2
- previous intolerance of moderate altitude (<3000m)

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01130948
Switzerland | |
University Hospital of Zurich, Pulmonary Division | |
Zurich, Switzerland, CH-8091 |
Principal Investigator: | Konrad E Bloch, Prof. MD | University Hospital Zurich, Pulmonary Division |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | University of Zurich |
ClinicalTrials.gov Identifier: | NCT01130948 |
Other Study ID Numbers: |
2010-0054/1 |
First Posted: | May 26, 2010 Key Record Dates |
Last Update Posted: | May 20, 2014 |
Last Verified: | May 2014 |
hypoxia altitude sleep sleep apnea |
periodic breathing vigilance psychomotor endothelial function |
Respiratory Aspiration Respiration Disorders Respiratory Tract Diseases Pathologic Processes |