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Sleep, Breathing and Psychomotor Performance at Altitude: A Physiologic Study in Healthy Subjects

This study has been completed.
Information provided by (Responsible Party):
University of Zurich Identifier:
First received: May 25, 2010
Last updated: May 18, 2014
Last verified: May 2014
This study investigates the effect of altitude exposure on sleep, breathing and psychomotor performance in healthy subjects.

Condition Intervention
Healthy Men Other: altitude exposure

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Outcomes Assessor)
Official Title: Sleep, Breathing and Psychomotor Performance at Altitude: A Physiologic Study in Healthy Subjects

Further study details as provided by University of Zurich:

Primary Outcome Measures:
  • apnea/hypopnea index [ Time Frame: day 1-4 at altitude ]
  • Reaction time [ Time Frame: day 1-4 at altitude ]
    psychomotor vigilance test reaction time

Secondary Outcome Measures:
  • Psychomotor vigilance [ Time Frame: day 1-4 at altitude ]
    performance in the Motor Task Manager test

  • sleep quality [ Time Frame: day 1-4 at altitude ]
    percent of slow wave sleep, araousal index

  • arterial applanation tonometry [ Time Frame: day 1-4 at altitude ]
    endothelial function and arterial stiffness

Enrollment: 51
Study Start Date: May 2010
Study Completion Date: October 2010
Primary Completion Date: October 2010 (Final data collection date for primary outcome measure)
Intervention Details:
    Other: altitude exposure
    exposure to 490m, 1700m and 2590m
Detailed Description:
Sleep is essential for well being and performance. Sleep disturbances by recurrent apnea and hypoxia in patients with obstructive sleep apnea syndrome impair quality of life, cognitive and cardiovascular functions. Similar consequences occur in healthy subjects exposed to hypoxia at altitude due to periodic breathing with recurrent central apnea. This project will investigate effects of altitude on sleep, breathing, psychomotor performance and on the cardiovascular system in healthy subjects and patients with sleep apnea. The results will help to better understand mechanisms of sleep disturbances and psychomotor impairment induced by hypoxia and to prevent adverse effects of altitude exposure.

Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • healthy men
  • residence at <800m

Exclusion Criteria:

  • any active disease requiring treatment
  • requirement for regular use of medication
  • smoking, regular intake of alcohol or drugs
  • body mass index <18 or >30 kg/m2
  • previous intolerance of moderate altitude (<3000m)
  Contacts and Locations
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Please refer to this study by its identifier: NCT01130948

University Hospital of Zurich, Pulmonary Division
Zurich, Switzerland, CH-8091
Sponsors and Collaborators
University of Zurich
Principal Investigator: Konrad E Bloch, Prof. MD University Hospital Zurich, Pulmonary Division
  More Information


Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: University of Zurich Identifier: NCT01130948     History of Changes
Other Study ID Numbers: 2010-0054/1
Study First Received: May 25, 2010
Last Updated: May 18, 2014

Keywords provided by University of Zurich:
sleep apnea
periodic breathing
endothelial function

Additional relevant MeSH terms:
Respiratory Aspiration
Respiration Disorders
Respiratory Tract Diseases
Pathologic Processes processed this record on September 20, 2017