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Pyruvate Kinase Isoform M2 (PKM2) as a Possible Biomarker for Cancer

This study has been completed.
Information provided by:
National University Hospital, Singapore Identifier:
First received: May 24, 2010
Last updated: December 10, 2013
Last verified: December 2013

The purpose of this study is to determine if pyruvate kinase M2 (PKM2) can be used as a biomarker in cancer.

Pyruvate kinase M2 is more elevated in malignant pleural fluid than in plasma, and may be a useful biomarker to distinguish between malignant and non-malignant causes of pleural effusion. In addition, pyruvate kinase M2 has also been found to be elevated in saliva in cancer patients compared to controls. Measuring pyruvate kinase M2 in saliva may be used to diagnose cancer or monitor the treatment progress of cancer.

Condition Intervention
Cancer Other: Pyruvate kinase isoform M2

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by National University Hospital, Singapore:

Study Start Date: April 2010
Study Completion Date: April 2013
Primary Completion Date: April 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Cancer patient Other: Pyruvate kinase isoform M2


Ages Eligible for Study:   21 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Any cancer patient

Inclusion Criteria:

  • Any cancer patient with pleural effusion that is being drained through an indwelling chest-tube in an inpatient ward.

Exclusion Criteria:

  • Patient with a pleural effusion who does not have proven cancer or whose pleural effusion is not known to be malignant.
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Please refer to this study by its identifier: NCT01130584

National University Hospital, Singapore
Singapore, Singapore
Sponsors and Collaborators
National University Hospital, Singapore