The Effects of Plant Bioactives on Platelet Function

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01130129
Recruitment Status : Completed
First Posted : May 25, 2010
Last Update Posted : March 6, 2013
European Union
Information provided by (Responsible Party):
Quadram Institute

Brief Summary:
Consumption of a diet rich in fruit and vegetables is associated with a reduced risk of cardiovascular disease and the protective effect may be due to polyphenolic compounds contained within these foods. The mechanism by which polyphenols exert this effect is not clearly understood but research has focused on their potential to affect platelet function. The purpose of this study is to quantify the anti-clotting activity of a range of plant food extracts and component compounds.

Condition or disease Intervention/treatment Phase
Healthy Other: Ex-vivo treatments with flavonoids Not Applicable

Detailed Description:
A single sample of whole blood will be collected from 15 male or female volunteers aged between 18 and 65 years. After collection whole blood will be treated with a range of flavonoids to evaluate their effects on platelet function.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 15 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: The Effects of Plant Bioactives on Platelet Function
Study Start Date : June 2010
Actual Primary Completion Date : June 2011
Actual Study Completion Date : June 2011

Arm Intervention/treatment
Experimental: Ex-vivo treatment of platelets
Ex-vivo treatment of platelets
Other: Ex-vivo treatments with flavonoids
Ex-vivo treatment of platelets with a range of flavonoids

Primary Outcome Measures :
  1. Identification of flavonoids that exert a significant anti-clotting effect [ Time Frame: within 4hours ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Males and females
  • Aged 18 - 65 years.
  • BMI > 19.5 and < 35
  • Non-smokers

Exclusion Criteria:

  • Pregnancy or have been pregnant within the last 12 months
  • Parallel participation in another research project which involves dietary intervention
  • Participation in another research project which has involved blood sampling within the last four months unless the total amount of combined blood from both studies does not exceed 470 mls.
  • Has donated or intends to donate blood within 16 weeks prior to during the Study period.
  • Depressed or elevated blood pressure measurements (<90/50 or 95/50 if symptomatic or >160/100)
  • Any person related to or living with any member of the study team
  • Diabetics
  • Taking regular prescribed and/or non-prescribed medication (excluding oral contraceptive and HRT).
  • Known bleeding disorders.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01130129

United Kingdom
Institute of Food Research
Norwich, Norfolk, United Kingdom, NR4 7UA
Sponsors and Collaborators
Quadram Institute
European Union
Principal Investigator: Paul Kroon, phD Quadram Institute

Responsible Party: Quadram Institute Identifier: NCT01130129     History of Changes
Other Study ID Numbers: IFR02/2009
First Posted: May 25, 2010    Key Record Dates
Last Update Posted: March 6, 2013
Last Verified: March 2013

Keywords provided by Quadram Institute: