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Saliva Composition and Oral Hygiene in Children With Celiac Disease Before and After the Change in Diet

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01129908
First Posted: May 25, 2010
Last Update Posted: December 20, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Moti Moskovitz, Hadassah Medical Organization
  Purpose

The celiac disease (CD) is a disease with an immune and genetic component that is activated by the presence of gluten, and damages the intestine mucosa and causes malabsorption of food.

In the oral environment the investigators see enamel defects and recurrent ulcers.

Celiac patients have to keep a restrict gluten-free diet, in order to prevent the clinical symptoms of the disease (such as diarrhea, stomach ache and weight loss).

It has been assumed that the patients have less cariogenic diet, and that caries prevalence is not as high as in normal population.

In celiac patients the investigators find enamel defects that are characterized with pits and deep fissures and sometimes the complete loss of enamel. These defects are classified by the grading of the CD related DED's (dental enamel defects) according to Aine. These defects are symmetrical defects in the permanent dentition, in teeth that develops at the same time. The cause is thought to be hypocalcaemia or genetic.

These defects were found in 42.2% of celiac patients in appose to only 5.4% in healthy population.

Recurrent ulcers were found in 41% in the oral cavity of celiac patients, compare to 27% in healthy population.

After changing the diet to a gluten-free diet, an improvement is seen in the presence of these ulcers.


Condition
Celiac Disease

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Saliva Composition and Oral Hygiene in Children With Celiac Disease Before and After the Change in Diet

Resource links provided by NLM:


Further study details as provided by Moti Moskovitz, Hadassah Medical Organization:

Enrollment: 90
Study Start Date: May 2010
Study Completion Date: July 2012
Primary Completion Date: July 2012 (Final data collection date for primary outcome measure)
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   3 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
chilren with celiac disease
Criteria

Inclusion Criteria:

  • celiac disease

Exclusion Criteria:

  • no other systemic condition
  • age 3-18
  • children on medication
  Contacts and Locations
No Contacts or Locations Provided
  More Information

Responsible Party: Moti Moskovitz, Clinical Senior Lecturer, Hadassah Medical Organization
ClinicalTrials.gov Identifier: NCT01129908     History of Changes
Other Study ID Numbers: odelia- HMO-CTIL
First Submitted: May 23, 2010
First Posted: May 25, 2010
Last Update Posted: December 20, 2016
Last Verified: December 2016

Keywords provided by Moti Moskovitz, Hadassah Medical Organization:
oral health in children with celiac disease

Additional relevant MeSH terms:
Celiac Disease
Malabsorption Syndromes
Intestinal Diseases
Gastrointestinal Diseases
Digestive System Diseases
Metabolic Diseases