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Canthaxanthin Retinopathy: A Long-term Observation

This study has been completed.
Information provided by:
University of Cologne Identifier:
First received: May 20, 2010
Last updated: NA
Last verified: May 2010
History: No changes posted
Canthaxanthine is a naturally occurring carotenoid that has been a popular over-the-counter oral artificial tanning agent in Europe, Canada, and Australia since 1979. It is also used at low dosage as a food-colouring agent and as a therapeutic agent for photosensitivity disorders such as erythropoietic protoporphyria. Canthaxanthin retinopathy was first described in 1982 by Cortin et al. In Germany the office of the federal board of health refused the permit for oral tanning agents containing canthaxanthine in 1985. At that time the long-term course of the disease was not known. 25 years later the investigators did these long-term follow-up examinations.

Canthaxanthin Retinopathy

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by University of Cologne:

Primary Outcome Measures:
  • all eye diseases [ Time Frame: 2008 and 2009 ]
    All patients will have the follow-up examination 2008 or 2009. The examination included at most visual acuity (distant and near vision), Amsler test, examination of anterior segment, posterior segment, 10-2 and 30-2 visual field, electrooculography, electroretinography, multifocal electroretinography, fundus photography, fluorescein angiography, and an examination for autofluorescence.

Enrollment: 35
Study Start Date: December 1983
Study Completion Date: May 2010
Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with a history of oral tanning agents should report at the University Eye hospital for examination.

Inclusion Criteria:

  • patients using oral tanning agents for at least 2 months.
  • patients of 18 years or older

Exclusion Criteria:

  Contacts and Locations
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Please refer to this study by its identifier: NCT01128062

University Eye Hospital, University of Cologne
Cologne, NRW, Germany, 50937
Sponsors and Collaborators
University of Cologne
  More Information Identifier: NCT01128062     History of Changes
Other Study ID Numbers: AHARMS-8310
Study First Received: May 20, 2010
Last Updated: May 20, 2010

Keywords provided by University of Cologne:
Canthaxanthin retinopathy

Additional relevant MeSH terms:
Retinal Diseases
Eye Diseases
Molecular Mechanisms of Pharmacological Action
Protective Agents
Physiological Effects of Drugs processed this record on September 21, 2017