SLC26 Anion Transporter Gene Variants to Idiopathic Calcium Oxalate Urolithiasis

This study is enrolling participants by invitation only.
Information provided by:
Mayo Clinic Identifier:
First received: May 20, 2010
Last updated: April 1, 2015
Last verified: April 2015
The goal of the study is to pilot test the collection of blood samples for DNA isolation from 100 patients presenting with idiopathic calcium urolithiasis (cases) and 100 patients with negative history and radiographically-confirmed absence of urolithiasis (controls).

Kidney Stones
Calcium Oxalate Urolithiasis

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Pilot Study to Evaluate the Contribution SLC26 Anion Transporter Gene Variants to Idiopathic Calcium Oxalate Urolithiasis in Humans

Resource links provided by NLM:

Further study details as provided by Mayo Clinic:

Biospecimen Retention:   Samples With DNA

Enrollment: 200
Study Start Date: December 2009
Estimated Study Completion Date: October 2015
Estimated Primary Completion Date: October 2015 (Final data collection date for primary outcome measure)

Detailed Description:
Idiopathic calcium oxalate urolithiasis affects 12% of men and 5% of women in the industrialized world. Familial aggregation patterns, and more recently, twin studies, have suggested a strong genetic basis. Recently, there has been an increasing appreciation of a family of anion transporters (Solute-Linked Carrier Family 26 or SLC26) with a capacity to transport oxalate. Indeed, published results from lab-based investigations support a role for variability in the activity of this family of anion transporters and level of oxalate in urine. The intriguing results from laboratory-based physiologic experiments not withstanding, to date there has been no attempt to directly evaluate the role of genetic variation in the SLC26 gene and risk of calcium oxalate urolithiasis. Motivated by this gap in the science, we ultimately seek to conduct a large, candidate gene case-control association study across two Mayo sites (Mayo Florida and Mayo Rochester).

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Mayo Clinic in Jacksonville, FL Mayo Clinic in Rochester, MN

Inclusion Criteria:


  • History of calcium oxalate stones
  • 18 years of age or older
  • Willing to provide a blood sample


  • Confirmed to have no presence of stones on abdominal radiographic imaging
  • 18 years of age or older
  • No personal history of urolithiasis
  • Willing to provide a blood sample

Exclusion Criteria:


  • Secondary causes of urolithiasis including: Bowel disease, Renal tubular acidosis, hyperparathyroidism
  Contacts and Locations
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Please refer to this study by its identifier: NCT01127854

United States, Florida
Mayo Clinic
Jacksonville, Florida, United States, 32224
United States, Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905
Sponsors and Collaborators
Mayo Clinic
Principal Investigator: William E Haley, MD Mayo Clinic
  More Information

No publications provided

Responsible Party: William E. Haley, MD, Mayo Clinic Identifier: NCT01127854     History of Changes
Other Study ID Numbers: 09-007826 
Study First Received: May 20, 2010
Last Updated: April 1, 2015
Health Authority: United States: Institutional Review Board

Keywords provided by Mayo Clinic:
kidney stone
calcium oxalate kidney stone
calcium oxalate stone
calcium oxalate
Solute-Linked Carrier Family 26

Additional relevant MeSH terms:
Kidney Calculi
Kidney Diseases
Pathological Conditions, Anatomical
Urinary Calculi
Urologic Diseases processed this record on February 08, 2016