Bariatric and Obstructive Lung Disease Study II (BOLD II)
Recruitment status was: Active, not recruiting
The prevalence of obesity and asthma has significantly increased over the past two decades. The purpose of this study is to try and understand the mechanism by which obesity leads to airway hyperresponsiveness (AHR), one of the defining features of asthma. This research is being done to determine how weight or body size affects airway size and airway smooth muscle (ASM) tone and function. The goal of the study will be to look at if and how, weight might affect lung functioning.
The investigators hypothesize that low lung volumes in obesity lead to AHR by reducing airway caliber causing increased ASM tone with impairment in deep inspiration (DI) response similar to what is seen in asthma.
|Study Design:||Observational Model: Cohort
Time Perspective: Cross-Sectional
|Official Title:||Effects of Obesity on Airway Caliber and Airway Smooth Muscle Tone|
|Study Start Date:||September 2009|
|Estimated Study Completion Date:||July 2012|
|Estimated Primary Completion Date:||July 2012 (Final data collection date for primary outcome measure)|
Participants that will have had a bariatric surgery but do not have asthma.
Participants that will have had a bariatric surgery and have been physician diagnosed with asthma prior to the surgery.
Healthy participants that who will not be getting a bariatric surgery and who do not have asthma.
Healthy participants that will not be having a bariatric surgery but do have asthma.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01127399
|United States, Maryland|
|The Johns Hopkins University, The Johns Hopkins Bayview Medical Campus|
|Baltimore, Maryland, United States, 21224|
|Principal Investigator:||Emmanuelle Clerisme-Beaty, MD, MHS||The Johns Hopkins University|