Bariatric and Obstructive Lung Disease Study II (BOLD II)
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|ClinicalTrials.gov Identifier: NCT01127399|
Recruitment Status : Terminated (Funding revoked)
First Posted : May 20, 2010
Last Update Posted : February 2, 2018
The prevalence of obesity and asthma has significantly increased over the past two decades. The purpose of this study is to try and understand the mechanism by which obesity leads to airway hyperresponsiveness (AHR), one of the defining features of asthma. This research is being done to determine how weight or body size affects airway size and airway smooth muscle (ASM) tone and function. The goal of the study will be to look at if and how, weight might affect lung functioning.
The investigators hypothesize that low lung volumes in obesity lead to AHR by reducing airway caliber causing increased ASM tone with impairment in deep inspiration (DI) response similar to what is seen in asthma.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||40 participants|
|Official Title:||Effects of Obesity on Airway Caliber and Airway Smooth Muscle Tone|
|Actual Study Start Date :||September 2009|
|Actual Primary Completion Date :||June 2011|
|Actual Study Completion Date :||June 2011|
Participants that will have had a bariatric surgery but do not have asthma.
Participants that will have had a bariatric surgery and have been physician diagnosed with asthma prior to the surgery.
Healthy participants that who will not be getting a bariatric surgery and who do not have asthma.
Healthy participants that will not be having a bariatric surgery but do have asthma.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01127399
|United States, Maryland|
|The Johns Hopkins University, The Johns Hopkins Bayview Medical Campus|
|Baltimore, Maryland, United States, 21224|
|Principal Investigator:||Emmanuelle Clerisme-Beaty, MD, MHS||The Johns Hopkins University|